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Question

A list of pathogens (Group I) and a list of anti-microbial agents (Group II) used to treat their infections are given below. Match the pathogens with the corresponding anti-microbial agents.
Group IGroup II
[P] Influenza A virus1. Isoniazid
[Q] Fungus2. Amantadine
[R] Plasmodium3. Fluconazole
[S] Mycobacterium4. Artemisinin
5. Iodoquinol

The correct answer is
P-2, Q-3, R-4, S-1

Matching Pathogens and Anti-microbial Agents

The question requires matching specific pathogens with their corresponding anti-microbial agents used for treatment.

Pathogen-Agent Pairings

  • Influenza A virus [P]: This viral infection is commonly treated with Amantadine [2].
  • Fungus [Q]: Fungal infections are treated with anti-fungal agents like Fluconazole [3].
  • Plasmodium [R]: This parasite, causing malaria, is effectively treated with Artemisinin [4].
  • Mycobacterium [S]: This genus includes bacteria like Mycobacterium tuberculosis, treated with anti-tubercular drugs such as Isoniazid [1].

Solution Summary

Based on the standard treatments for these pathogens:

  • [P] Influenza A virus matches with [2] Amantadine.
  • [Q] Fungus matches with [3] Fluconazole.
  • [R] Plasmodium matches with [4] Artemisinin.
  • [S] Mycobacterium matches with [1] Isoniazid.

This corresponds to the pairing P-2, Q-3, R-4, S-1.

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Important Questions from Antibiotics and Antimicrobial Resistance

  1. Which one of the following antibiotics blocks protein chain elongation by preventing the action of peptidyl transferase ?
  2. Match the antibiotics in Group I with their modes of action in Group II.

    Group IGroup II
    P) Chloramphenicol 1) Inhibits protein synthesis by acting on 30S ribosomal subunit 
    Q) Rifampicin 2) Interferes with DNA replication by inhibiting DNA gyrase 
    R) Tetracycline 3) Inhibits protein synthesis by acting on 50S ribosomal subunit 
    S) Quinolone4) Interferes with RNA polymerase activity 
     5) Inhibits $\beta$-lactamase activity

     

  3. Which of the following statement(s) is(are) TRUE about fluoroquinolone drugs?
  4. A bacterial culture (200 µl containing $1.8 \times 10^9$ cells) was treated with an antibiotic Z (50 µg per ml) for 4 h at 37°C. After this treatment, the culture was divided into two equal aliquots. 

    Set A: 100 µl was plated on Luria agar. 

    Set B: 100 µl was centrifuged, the cell pellet washed and plated on Luria agar. 

    After incubating these two plates for 24 h at 37°C, Set A plate showed no colonies, whereas the Set B plate showed $0.9 \times 10^9$ cells. This experiment showed that the antibiotic Z is

  5. Which of the following antimicrobial agent(s) is/are growth factor analog(s)?
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