Match List I with List II and select the correct answer using the code given below the Lists:List I (Class of drugs) List II (Anti retroviral agents) A. Nucleoside analogue Reverse Transcriptase Inhibitor 1. Stavudin B. Nucleotide analogue Reverse Transcriptase Inhibitor 2. Nevirapine C. Non-Nucleotide Reverse Transcriptase Inhibitor 3. Lopanavir D. Protease Inhibitor 4. Tenofovir
A-1, B-4, C-2, D-3
Matching Anti-Retroviral Drug Classes and Agents
The question requires matching the classes of anti-retroviral drugs in List I with their corresponding examples in List II.
Analysis of Drug Classes:
- A. Nucleoside analogue Reverse Transcriptase Inhibitor (NRTI): These are drugs that mimic natural nucleosides and inhibit the reverse transcriptase enzyme. Stavudine is a classic example.
- B. Nucleotide analogue Reverse Transcriptase Inhibitor (NtRTI): Similar to NRTIs, but they are nucleotide analogues. Tenofovir is a primary example of an NtRTI.
- C. Non-Nucleotide Reverse Transcriptase Inhibitor (NNRTI): These drugs bind directly to the reverse transcriptase enzyme at a site different from NRTIs, inhibiting its function. Nevirapine belongs to this class.
- D. Protease Inhibitor (PI): These drugs block the viral protease enzyme, preventing the maturation of new virus particles. Lopinavir is a well-known protease inhibitor.
Correct Matching:
- A (NRTI) matches with 1 (Stavudine).
- B (NtRTI) matches with 4 (Tenofovir).
- C (NNRTI) matches with 2 (Nevirapine).
- D (PI) matches with 3 (Lopinavir).
Therefore, the correct combination is A-1, B-4, C-2, D-3.
Final Answer Selection
Based on the matching:
| A | B | C | D |
| 1 | 4 | 2 | 3 |
This corresponds to Option 2.
Important Questions from Viral Infections
- A 26-year old HIV infected male presents with odynophagia. Upper GI endoscopy demonstrates serpiginous ulcers in a normal surrounding mucosa in distal esophagus. The most likely diagnosis is:
- Cytomegalovirus esophagitis is particularly common in which group of patients?
- Which one of the following is a cause of early (0–4 weeks) infection in recipients of haematopoietic stem cell transplantation?
A 16-year old boy presented with fever and a diffuse maculopapular rash. Examination revealed generalised cervical lymphadenopathy and hepatosplenomegaly. After intake of Ampicillin (prescribed by a local practitioner), the rash worsened. The most likely diagnosis is:
Which one of the following antiretroviral drugs is a Nucleoside reverse transcriptase inhibitor?
