In primary immune response, how much more antigenic dose is required to induce IgG antibodies as against the induction of IgM antibodies?
Primary Immune Response: IgM vs IgG Antibody Induction
In the initial phase of a primary immune response, the body first produces IgM antibodies upon encountering an antigen. These IgM antibodies are crucial for the early defense.
Antigenic Dose Requirements
Following the IgM response, B cells undergo a process called class switching, which leads to the production of IgG antibodies. This class switching and subsequent IgG production typically requires more significant or sustained antigenic stimulation compared to the initial IgM response.
- IgM Production: Induced relatively easily with a lower antigenic dose.
- IgG Production: Requires a substantially higher antigenic dose compared to IgM.
Dose Multiplier for IgG
Studies and immunological principles indicate that the amount of antigenic dose required to effectively induce IgG antibodies in a primary response is considerably greater than that needed for IgM antibodies. This dose requirement is often cited as being approximately 50 times higher.
Therefore, to achieve IgG antibody induction, a dose approximately 50 times larger than that needed for initial IgM production is generally required.
Important Questions from Preventive Medicine
Consider the following statement :
"The people should seek to preserve their traditional eating patterns and life-styles associated with low levels of Coronary Heart Disease (CHD)."
Which level of prevention is implied in this statement?
- Which of the following criteria must be met by a disease before it is to be considered suitable for a screening programme?
1. The natural history of the disease should be adequately understood.
2. No effective treatment should exist for the disease.
3. The disease should not have a recognizable latent or asymptomatic stage.
4. There should be a test that can detect the disease prior to onset of signs and symptoms.
Select the correct answer using the code given below. - Determination of alpha-fetoprotein levels in maternal serum is a useful screening tool for
- Which among the following is/are the examples of primordial prevention ?
1. Adopting healthy lifestyles from childhood
2. Immunization of infants
3. Screening of cervical cancer
Select the correct answer using the code given below: - What is the correct sequence of the following levels of prevention?
1. Specific protection
2. Early diagnosis and prompt treatment
3. Disability limitation and rehabilitation
4. Health promotion
Select the correct sequence from the code given below:
