Assertion (A) : The fundamental goal of a dose - response assessment is to obtain a mathematical relationship between the amount of a toxicant that a human is exposed to and the risk that there will be.
Reason (R) : To apply dose - response data obtained from animal bioassay to humans, a scaling factor must be introduced.
Choose the correct answer :
Assertion (A) Analysis
The assertion states that the primary aim of dose-response assessment is to establish a mathematical link between the quantity of a toxic substance exposure and the probability of a harmful effect (risk) in humans. This is accurate, as quantifying this relationship is fundamental to risk assessment.
Reason (R) Analysis
The reason points out the necessity of using a scaling factor when applying data from animal toxicity tests (bioassays) to predict effects in humans. This is also correct, as physiological differences between species necessitate adjustments, often using uncertainty or extrapolation factors, to estimate human risk from animal data.
Relationship Between Assertion (A) and Reason (R)
While both statements are factually correct:
- Assertion (A) defines the fundamental goal of dose-response assessment: establishing the dose-risk relationship.
- Reason (R) describes a specific methodological requirement (using scaling factors) for extrapolating data, particularly from animal studies, which is a component *within* the broader process of dose-response assessment but not the definition or explanation of its core goal.
Therefore, Reason (R) is correct but does not serve as the explanation for Assertion (A).
Important Questions from Toxic Chemicals - Teaching
- Match the LIST-I with LIST-II
LIST-I LIST-II A. Dichlorvos I. Type A organophosphate insecticide B. Melathion II. Type B organophosphate insecticide C. Parathion III. Type C organophosphate insecticide D. Lindane IV. Organochlorine Insecticide
Choose the correct answer from the options given below: - Which of the following is most important analog of DDT that have same general size, shape and possess the same insecticidal properties but is more biodegradable and less bioaccumulative ?
- A toxic substance is present at 10 mg/l (=10ppm) level in water. Arrange the following subjects (A, B, C, D and E) in decreasing order of their daily dose in (mg kg⁻¹ day⁻¹) of this substance.
A. Subject taking 2 liters of water per day and have body weight of 50 kg.
B. Subject taking 2 liters of water per day and have body weight of 70 kg.
C. Subject taking 1 liters of water per day and have body weight of 10 kg.
D. Subject taking 5 liters of water per day and have body weight of 100 kg.
E. Subject taking 1 liters of water per day and have body weight of 70 kg.
Choose the correct answer from the options given below: - Which of the following statement is incorrect ?
- The most common form of lead present in pesticide is :
