Question
Consider the following statements with regard to Amphotericin B :
1. It is a narrow spectrum antifungal agent.
2. It can cause nephrotoxicity.
3. It lacks an oral preparation.
4. Its lipid formulations are less toxic.
Select the correct answer using the code given below:
The correct answer is
2, 3 and 4
Amphotericin B Properties Analysis
Let's analyze the given statements about Amphotericin B:
- Statement 1: It is a narrow spectrum antifungal agent. This statement is incorrect. Amphotericin B is known for its broad-spectrum activity against a wide range of fungi, including yeasts and molds.
- Statement 2: It can cause nephrotoxicity. This statement is correct. Nephrotoxicity (kidney damage) is a well-documented and significant side effect associated with Amphotericin B therapy.
- Statement 3: It lacks an oral preparation. This statement is correct. Amphotericin B has very poor oral bioavailability and is primarily administered via intravenous infusion for systemic infections. Oral preparations are not typically used for systemic treatment.
- Statement 4: Its lipid formulations are less toxic. This statement is correct. Lipid formulations of Amphotericin B (such as liposomal Amphotericin B) were developed to mitigate the severe toxicity, particularly nephrotoxicity, associated with the conventional deoxycholate formulation.
Final Conclusion
Statements 2, 3, and 4 are accurate descriptions of Amphotericin B.
The correct selection consists of the accurate statements: 2, 3, and 4.
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