1. It is a narrow spectrum antifungal agent.
2. It can cause nephrotoxicity.
3. It lacks an oral preparation.
4. Its lipid formulations are less toxic.
Select the correct answer using the code given below:
Amphotericin B Properties Analysis
Let's analyze the given statements about Amphotericin B:
- Statement 1: It is a narrow spectrum antifungal agent. This statement is incorrect. Amphotericin B is known for its broad-spectrum activity against a wide range of fungi, including yeasts and molds.
- Statement 2: It can cause nephrotoxicity. This statement is correct. Nephrotoxicity (kidney damage) is a well-documented and significant side effect associated with Amphotericin B therapy.
- Statement 3: It lacks an oral preparation. This statement is correct. Amphotericin B has very poor oral bioavailability and is primarily administered via intravenous infusion for systemic infections. Oral preparations are not typically used for systemic treatment.
- Statement 4: Its lipid formulations are less toxic. This statement is correct. Lipid formulations of Amphotericin B (such as liposomal Amphotericin B) were developed to mitigate the severe toxicity, particularly nephrotoxicity, associated with the conventional deoxycholate formulation.
Final Conclusion
Statements 2, 3, and 4 are accurate descriptions of Amphotericin B.
The correct selection consists of the accurate statements: 2, 3, and 4.
Important Questions from Fungal Infections
- Which of the following opportunistic systemic mycoses is characterized by rapid development of severe tissue necrosis and emerged as specific complication associated with COVID-19 infection in India?
- Which of the following fungal infections is caused by dermal inoculation of the fungal agent, usually from a thorn?
Consider the following statements with regard to coccidioidomycosis:
1. It is a primary systemic mycosis caused by dimorphic fungi Cocci- dioides immitis and Coccidioides posadasii.
2. Primary pulmonary coccidioido- mycosis presents with cough, fever, chest pain and arthritis.
3. Progressive pulmonary coccidioido- mycosis presents with constitu- tional symptoms like fever, weight loss, anorexia and features of lobar pneumonia.
4. Coccidioides meningitis is a mild disease, not warranting any treatment.
Which of the statements given above are correct?
- A patient receiving chemotherapy develops neutropenia. He presents with fever, cough, expectoration, chest pain and hemoptysis. His CT scan of chest reveals nodular infiltrates with halo sign and crescent sign. The most useful drug for treating him is
- Which one of the following moulds causes mucormycosis, commonly known as 'black fungus'?
