Question
Antifungal agent of choice for the treatment of mucormycosis is:
The correct answer is
Amphotericin-B
Antifungal Agent Choice for Mucormycosis Treatment
Mucormycosis, a severe and invasive fungal infection, requires prompt and effective treatment. The choice of antifungal medication is critical for patient outcomes.
Primary Treatment Agent
The antifungal agent generally considered the first-line treatment or agent of choice for mucormycosis is Amphotericin-B.
Rationale and Options Analysis
- Amphotericin-B: This broad-spectrum antifungal is highly effective against the causative fungi (species of Mucorales). It is typically administered intravenously and remains the cornerstone of therapy, especially for severe infections.
- Azole Antifungals (Voriconazole, Intraconazole, Fluconazole):
- Fluconazole: Has very limited activity against Mucorales and is not considered effective for mucormycosis.
- Voriconazole: Shows some activity but is generally less effective than Amphotericin-B and is often reserved for salvage therapy or specific cases.
- Intraconazole: May have activity against some Mucorales, but Amphotericin-B is preferred due to superior efficacy and established role in treatment.
While other antifungals might be used in specific contexts or as secondary options, Amphotericin-B is the established agent of choice due to its proven efficacy against this dangerous infection.
Conclusion
Based on clinical guidelines and efficacy data, Amphotericin-B is the recommended antifungal agent for treating mucormycosis.
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Important Questions from Fungal Infections
- A 32-year old HIV infected male presents with shortness of breath and moderate fever of two- week duration. On examination, cyanosis is present, with respiratory rate of 22/minute and some basal crackles in chest. The CT chest shows bilateral ground-glass pattern. The most likely etiologic diagnosis is:
- Cryptococcal infection is acquired through:
- Echinocandins are a class of:
- Consider the following statements with regard to Amphotericin B :
1. It is a narrow spectrum antifungal agent.
2. It can cause nephrotoxicity.
3. It lacks an oral preparation.
4. Its lipid formulations are less toxic.
Select the correct answer using the code given below: - Which one of the following moulds causes mucormycosis, commonly known as 'black fungus'?
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