Consider the following statements regarding organophosphate-induced delayed polyneuropathy (OPIDN) : 1. It is a rare complication and occurs 2 - 3 weeks after acute exposure. 2. It is a feature of poisoning with certain organophosphorus compounds such as triorthocresyl phosphate. 3. Inhibition of acetylcholinesterase causes motor polyneuropathy with no evidence of sensory loss. 4. There is no specific therapy although regular physiotherapy may limit deformity caused by muscle wasting. Which of the statements given above are correct?
OPIDN Statements Analysis
This question requires evaluating four statements about organophosphate-induced delayed polyneuropathy (OPIDN) to identify the correct ones.
Statement Evaluation:
- Statement 1: Correct. OPIDN is indeed a known, though relatively rare, complication that typically manifests 2 to 3 weeks after significant exposure to specific organophosphates.
- Statement 2: Correct. OPIDN is characteristically associated with certain organophosphorus compounds, with triorthocresyl phosphate (TOCP) being a classic example historically linked to outbreaks.
- Statement 3: Incorrect. While organophosphates acutely inhibit acetylcholinesterase (AChE), OPIDN results from a different mechanism involving inhibition of Neuropathy Target Esterase (NTE). Furthermore, OPIDN typically involves both motor and sensory polyneuropathy, not just motor with no sensory loss.
- Statement 4: Correct. There is no specific antidote or cure for OPIDN itself. Management focuses on supportive care, including physiotherapy to manage muscle wasting and prevent deformities.
Conclusion
Based on the analysis, statements 1, 2, and 4 are correct. Statement 3 is incorrect due to the mechanism and symptom description.
Therefore, the correct option is the one that includes statements 1, 2, and 4.
Important Questions from Chemical Poisoning
- The toxic effects of aluminium phosphide is due to the release of:
- Use of calcium carbide for the artificial ripening of fruits is banned but it is often reported to be illegally used. What is/are the likely health hazards of exposure to this chemical?
1. Permanent damage to the eyes
2. Pulmonary edema
3. Irritation of mouth, throat and nose
Select the correct answer using the codes given below: - Which of the following statements is correct regarding Malachite that is used as food adulterant?
Which of the following parts of the human body can be used as a sample/samples for the presence of mercury?
1. Blood
2. Hair
3. Nail
Select the correct answer using the code given below:
Consider the following statements:
1. All organochlorine pesticides (OCPs) enter the human bodies through food chain only.
2. Some of the OCPs are categorized as Persistent Organic Pollutants.
Which of the statements given above is/are correct?
