1 Cystic fibrosis Autosomal recessive 2 Huntington's chorea Autosomal dominant 3 Marfan's syndrome Recessive sex-linked
Genetic Diseases and Mendelian Inheritance Analysis
This solution examines the provided pairs of genetic diseases and their associated Mendelian inheritance patterns to determine the number of correctly matched pairs.
Inheritance Pattern Verification
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Pair 1: Cystic fibrosis - Autosomal recessive
Cystic fibrosis is a well-established genetic disorder inherited in an autosomal recessive pattern. This means an individual must inherit two copies of the mutated gene (one from each parent) to develop the condition. This pair is correctly matched. -
Pair 2: Huntington's chorea - Autosomal dominant
Huntington's chorea is characterized by its autosomal dominant inheritance. Only one copy of the mutated gene is sufficient to cause the disease. This pair is correctly matched. -
Pair 3: Marfan's syndrome - Recessive sex-linked
Marfan syndrome is typically caused by mutations in the FBN1 gene and follows an autosomal dominant inheritance pattern. It is not a recessive sex-linked disorder. This pair is incorrectly matched.
Conclusion on Correctly Matched Pairs
Based on the analysis:
- Pair 1 is correctly matched.
- Pair 2 is correctly matched.
- Pair 3 is incorrectly matched.
Therefore, exactly two pairs are correctly matched.
Important Questions from Genetic Disorders & Public Health
- Which one of the following conditions is NOT inborn error of metabolism?
- Amniocentesis is called for in all of the following circumstances EXCEPT:
Consider the following statements :
Statement I:
Signs of thalassemia major usually develop after 6 months of age.
Statement II:
This is the time when haemoglobin synthesis switches from haemo-globin F to haemoglobin A.
Which one of the following is correct in respect of the above statements?
- Cystic fibrosis involves which of the following organs?
1. Lungs
2. Liver
3. Pancreas
4. Kidney
Select the correct answer using the code given below. - Which of the following statements are correct in respect of haemophilia?
1. It is hereditary bleeding disorder.
2. It has a higher incidence among Asians.
3. It affects females occasionally and mildly.
Select the correct answer using the code given below.
