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Question

As per the Open Vial Policy, partially used multidose vials of which of the following vaccines can be used over more than one immunization session? 

1. BCG vaccine 

2. DPT vaccine 

3. Hepatitis B vaccine 

4. Measles vaccine 

Select the correct answer using the code given below.

The correct answer is
2 and 3 only

Vaccine Open Vial Policy Explained

The Open Vial Policy refers to guidelines on using partially used multidose vaccine vials across multiple immunization sessions. This policy aims to minimize vaccine wastage while ensuring safety and efficacy.

Vaccines Suitable for Multi-Session Use

According to standard vaccination guidelines, multidose vials of certain vaccines can be used for more than one session if specific storage and handling conditions are met. These typically include:

  • DPT vaccine (Diphtheria, Pertussis, Tetanus)
  • Hepatitis B vaccine

These vaccines, when supplied in multidose vials, are formulated to remain stable for a defined period (often up to 28 days) after opening, provided they are stored correctly (e.g., refrigerated) and aseptic techniques are used for each withdrawal.

Vaccines NOT Suitable for Multi-Session Use

Some vaccines require single-dose vials or are not recommended for use across multiple sessions due to factors like:

  • BCG vaccine: Highly sensitive to light and contamination. Often supplied in single-dose vials after reconstitution.
  • Measles vaccine: Also sensitive to heat and light. Typically comes in single-dose vials and requires careful handling after reconstitution.

Conclusion

Based on the Open Vial Policy, only the DPT vaccine (2) and Hepatitis B vaccine (3) from the list can be used across multiple immunization sessions from a single multidose vial, assuming proper storage and aseptic technique.

Therefore, the correct option is the one that includes only vaccines 2 and 3.

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Important Questions from Infectious Disease Control & Prevention

  1. Consider the following statements regarding dengue virus : 

    1. It has four distinct serotypes. 

    2. Infection with any one serotype confers lifelong immunity for that virus serotype. 

    3. Secondary infection with dengue serotype 2 leads to severe form of dengue. 

    Which of the statements given above are correct?

  2. Consider the following statements regarding dengue : 

    1. The mosquito becomes infective after an extrinsic incubation period of 8-10 days. 

    2. Once it becomes infective, the mosquito remains infective for life. 

    3. The genital tract of the mosquito does not get infected. 

    Which of the statements given above are correct?

  3. Consider the following statements about Kyasanur Forest Disease (KFD) : 

    1. It is transmitted by ticks. 

    2. It was originally called 'pig disease' because of the association with dead pigs. 

    3. It was first recognized in Karnataka State. 

    How many of the statements given above are correct?

  4. In countries with low levels of measles transmission, what should be the appropriate age for starting immuni-zation with measles-containing vaccine (MCV)?
  5. Monkeypox, a viral zoonotic disease, is caused by
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