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Question

Arrange the following 'relationships to the proband', in descending order with respect to the proportion of genes inherited from the common ancestor-

 A. Second Cousin 

B. Half Sib

 C. Monozygotic twin 

D. Dizygotic twin 

Choose the correct answer from the options given below:

The correct answer is
C, D, B, A

Genetic Relatedness Ranking

The question requires arranging specific genetic relationships in descending order based on the proportion of genes inherited from a common ancestor. This order is determined by the degree of genetic relatedness between the individuals involved.

Proportion of Shared Genes Analysis

The standard proportion of genes shared (relatedness coefficient, denoted as $\textit{r}$) for each relationship type is as follows:

  • Monozygotic twin (C): Share approximately 100% of their genes ($\textit{r} = 1.0$). They originate from a single fertilized egg.
  • Dizygotic twin (D): Share approximately 50% of their genes on average ($\textit{r} = 0.5$). They develop from two separate fertilized eggs, similar to fraternal siblings.
  • Half Sib (B): Share approximately 25% of their genes on average ($\textit{r} = 0.25$). They have only one biological parent in common.
  • Second Cousin (A): Share approximately 6.25% of their genes on average ($\textit{r} = 0.0625$). Their common ancestors are typically great-grandparents.

Determining Descending Order

To find the descending order, we compare the relatedness coefficients:

  • C: $\textit{r} = 1.0$
  • D: $\textit{r} = 0.5$
  • B: $\textit{r} = 0.25$
  • A: $\textit{r} = 0.0625$

Arranging these from the highest proportion to the lowest gives the order: $1.0 > 0.5 > 0.25 > 0.0625$.

Mapping this back to the relationship labels, the correct descending order is C, D, B, A.

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Important Questions from Human genetics

  1. Match List - I with List - II :
    List - IList - II
    (a) Klinefelter Syndrome(i) trisomy 21
    (b) Turner Syndrome(ii) xxy
    (c) Down Syndrome(iii) xo
    (d) Phenylketonuria(iv) xyy
    (v) Inability to metabolize auinoacid

    Code :
  2. Sex chromosome anomaly (XXY) results into the development of :
  3. The pattern of DNA polymorphisms in a single chromosome is called:
  4. Match the LIST-I with LIST-II
    LIST-I (Scholars)LIST-II (Area of Research)
    A. S.C. TewariI. Paleoanthropology
    B. S.R.K. ChopraII. High Altitude Adaptation
    C. D.P. MukherjeeIII. Biochemical Genetics
    D. Amitabha BasuIV. Dermatoglyphics
    Choose the correct answer from the options given below:
  5. Sampling of 200 persons for their ABO blood group was done from an urban area. The types of blood group observed in the given population are as follows:

    A = 60, B = 32, AB = 10 and O = 98

    Which of the following gives the correct frequency of blood group determining alleles IA , IB and IO in the given population?

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