Question
All of the following are true about Bedaquiline (BDQ) EXCEPT:
The correct answer is
It is a bacteriostatic drug
Bedaquiline Properties Analysis
The question asks to identify the statement that is NOT true about Bedaquiline (BDQ). Bedaquiline is a crucial drug in tuberculosis (TB) treatment.
Identifying the Incorrect Statement
- Option B: It is a bacteriostatic drug - This statement is incorrect. Bedaquiline (BDQ) is classified as a bactericidal agent, meaning it actively kills Mycobacterium tuberculosis, rather than just inhibiting its growth.
Rationale for Correctness of Other Options
The following statements are true regarding Bedaquiline:
- Option 1: It specifically targets mycobacterial ATP synthase - BDQ's primary mechanism of action involves inhibiting the proton pump of the mycobacterial ATP synthase enzyme. This disrupts the bacterium's energy production.
- Option 3: It has extended half life - Bedaquiline possesses a long elimination half-life, approximately 5.5 months. This characteristic allows for intermittent dosing regimens.
- Option 4: It has high volume of tissue distribution - Clinical studies show that BDQ distributes extensively into various body tissues, which is consistent with its pharmacological profile.
Therefore, the only statement that is false about Bedaquiline is that it is a bacteriostatic drug.
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Important Questions from Infectious Disease Control & Prevention
- Consider the following statements regarding needle stick injuries:
1. Injured part should be washed under running water
2. Dominant index finger is the commonest site for needle stick injury
3. All needle stick injuries should be reported
4. Hepatitis/HIV testing should be done after needle stick injury
Which of the statements given above are correct? - Which one of the following is NOT a contagious disease?
- Pentavalent vaccine provides protection against which of the following diseases?
- Which one of the following statements regarding Rabies Immunoglobulin is NOT true?
Visual inspection based screening test with 5% acetic acid is used for the screening of which one of the following cancers?
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