Aeroallergens result in manifestation of allergic reactions ......... group of antibodies attach to these allergens and release inflammable chemicals such as histamine from mast cells.
IgE
Aeroallergens such as pollen, fungal spores and house-dust mite particles trigger a type I (immediate) hypersensitivity reaction in sensitised people.
During sensitisation, B cells produce immunoglobulin E (IgE). IgE binds through its Fc region to high-affinity receptors on mast cells and basophils.
On re-exposure, the allergen cross-links the bound IgE molecules, and the mast cells degranulate, releasing histamine, leukotrienes and prostaglandins that cause sneezing, wheezing, itching and swelling.
IgM is the large pentameric antibody of the primary immune response, IgG is the most abundant serum antibody and the only class that crosses the placenta, and IgA protects mucosal surfaces and is found in secretions such as saliva and milk. None of these is the class that sensitises mast cells.
Hence, IgE.
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