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Question

A large proportion of individuals in a particular population of humans carry the allele for colour-blindness. Assuming colour-blindness does not confer any evolutionary advantage, which of the following mechanisms CANNOT explain the unusual abundance of this allele?

The correct answer is
Purifying selection

Examining Allele Frequency Mechanisms

The question asks to identify the mechanism that CANNOT explain why an allele for a disadvantageous trait, such as colour-blindness, is unusually abundant in a human population, given that the allele confers no evolutionary advantage.

  • Founder effect: This can cause specific alleles, even rare or disadvantageous ones, to become common in a new population if the small group of founders happened to possess a high frequency of that allele.
  • Genetic drift: Random chance events can cause allele frequencies to fluctuate, especially in smaller populations. This random fluctuation can lead to an increase in the frequency of a disadvantageous allele over time.
  • Genetic hitchhiking: This occurs when an allele increases in frequency because it is located near a gene that is under positive selection. Even if the allele itself is neutral or slightly disadvantageous, it can increase in frequency if it's linked to a strongly favoured allele.
  • Purifying selection: This is a form of natural selection that acts to eliminate deleterious alleles (harmful mutations) from a population. It works to decrease the frequency of disadvantageous alleles.

Purifying selection directly opposes the increase in frequency of disadvantageous alleles. Therefore, it cannot explain the unusual abundance of the colour-blindness allele.

Correct Answer: D
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Important Questions from Genetic drift

  1. Which one of the following statements about genetic drift is accurate?
  2. A few years ago, a very small population of zebrafish became isolated by a newly built dam. As a result, which statement is most likely to be true about this population of zebrafish now?
  3. Which two of the following processes can result in a decline in heterozygosity in populations?
    I) inbreeding; II) genetic drift; III) mutation; IV) random mating
  4. In a population of birds on an island, the average beak size reduced over one generation. A researcher estimated the association between beak size and relative fitness, shown in the graph. The estimated slope was –0.05 with a 95% confidence interval of -0.15 to 0.09. 

    Which one of the following evolutionary processes acting on beak size is the most likely reason for the observed reduction in beak size?

  5. Two isolated populations X and Y have 100 and 10000 individuals, respectively. Both populations have the same starting allele frequencies of p=0.5 and q=0.5. After 1000 generations of genetic drift, which of the following statements is true about the heterozygosity at this locus in these two populations?
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