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Question

A gene duplication event in an organism results in two copies of a gene. Which one (or more) of the following outcomes is/are possible for the duplicated copy?

Gene Duplication: Possible Outcomes

Gene duplication is a fundamental process in evolution that creates genetic redundancy. When a gene is duplicated, the resulting two copies can follow several distinct evolutionary paths. Understanding these paths is crucial for comprehending gene evolution and the emergence of new functions.

Analysis of Possible Outcomes

After a gene duplication event, the fate of the duplicated gene copy can vary. The primary possibilities include:

  • Retaining Original Function: One copy may continue to perform the essential function of the original gene. This ensures the organism's normal physiological processes are maintained, as the original function is still covered.
  • Acquiring a New Function (Neofunctionalization): The duplicated copy is initially redundant. Freed from the strong selective pressure to maintain the original function, it can accumulate mutations. These mutations might lead to a novel, beneficial function, expanding the organism's capabilities.
  • Losing Function (Pseudogenization): The duplicated copy may accumulate mutations that render it non-functional. Without the selective pressure to maintain its original role (since the other copy is functional), these non-functional copies, known as pseudogenes, can persist in the genome.

Incorrect Outcome

The outcome "It gets translated but not transcribed" is generally not considered a direct consequence of gene duplication for a functional gene copy. Transcription (DNA to messenger RNA) is a necessary step before translation (mRNA to protein) can occur for a standard gene. A DNA sequence that is only translated implies a different molecular mechanism or a heavily mutated/non-standard genetic element, rather than a typical functional outcome of duplication.

Summary of Correct Outcomes

Therefore, the plausible outcomes for a duplicated gene copy are retaining the original function, evolving a new function, or losing function altogether.

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Important Questions from Mutation

  1. Which one of the following mechanisms is expected to generate tightly linked genes?
  2. In a population, there are two morphs, A and B, which reproduce at equal rates. A mutates to B with probability $p_1$, and B mutates to A with probability $p_2$ such that $p_1 \gg p_2$ (that is, $p_1$ is much greater than $p_2$). Over time, which one of the following statements would be true about this population?
  3. A gene coding for a particular protein exhibits 2% DNA sequence divergence between humans and chimpanzees. However, protein sequences encoded by them are identical. Which one of the following processes explains this?
  4. Gene conversion can lead to which one or more of the following evolutionary outcomes?
  5. For a given gene there is 5% DNA sequence divergence between two species, however the protein coded by this gene has identical sequences in the two species. Which of the following types of mutations best explains this pattern in the DNA sequence?
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