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Question

In a population, there are two morphs, A and B, which reproduce at equal rates. A mutates to B with probability $p_1$, and B mutates to A with probability $p_2$ such that $p_1 \gg p_2$ (that is, $p_1$ is much greater than $p_2$). Over time, which one of the following statements would be true about this population?

The correct answer is
Morph B will dominate the population.

Morph B Dominance Explained

This question relates to population genetics, specifically the effect of mutation rates on the relative abundance of different morphs (forms) within a population.

Mutation Dynamics

We have two morphs, A and B, in a population. They mutate between each other:

  • Morph A mutates to Morph B with probability $p_1$.
  • Morph B mutates to Morph A with probability $p_2$.

The problem states that $p_1 \gg p_2$, meaning the mutation rate from A to B is significantly higher than the mutation rate from B to A.

Analysis of Morph Frequencies

Although both morphs reproduce at equal rates, the mutation process continuously converts morphs from one form to another.

  • The forward mutation (A to B) occurs at a high rate ($p_1$).
  • The reverse mutation (B to A) occurs at a very low rate ($p_2$).

This results in a net flow of individuals from morph A to morph B over time. The high rate of A converting to B, coupled with the low rate of B converting back to A, creates a strong 'mutation pressure' favoring morph B.

Conclusion

Because there is a constant and strong net conversion of morph A into morph B, morph B will tend to increase in frequency relative to morph A. Therefore, over time, Morph B will dominate the population.

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Important Questions from Mutation

  1. Assume that the human haploid genome is $3 \times 10^9$ base pairs long. The mutation rate, when DNA is copied, is $5 \times 10^{-11}$ per base pair per replication. Based on these numbers, the expected number of mutations that take place per replication of the human haploid genome is _______ 

    (Round off to two decimal places)

  2. A gene coding for a particular protein exhibits 2% DNA sequence divergence between humans and chimpanzees. However, protein sequences encoded by them are identical. Which one of the following processes explains this?
  3. Gene conversion can lead to which one or more of the following evolutionary outcomes?
  4. Which one of the following Mendelian disorders is influenced by diet?
  5. Which one of the following mammalian DNA regions exhibits the highest level of sequence variation?
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