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Question

A 21-year-old man presents with recurrent episodes of intensely pruritic vesicles symmetrically distributed over the trunk. On electron microscopy, granular deposition of IgA and complement is noted at the mucoepidermal junction. Which of the following underlying conditions predisposes patients to the described skin disorder ?

The correct answer is
Celiac sprue

Identifying the Skin Disorder

The described condition features recurrent, intensely pruritic vesicles on the trunk, symmetrically distributed. Key diagnostic findings include granular deposition of IgA and complement at the mucoepidermal junction observed under electron microscopy. These features are classic indicators of Dermatitis Herpetiformis (DH).

Connecting DH to Predisposing Conditions

Dermatitis Herpetiformis is widely known as the specific cutaneous manifestation linked to celiac sprue (also referred to as celiac disease). Patients diagnosed with DH frequently exhibit underlying celiac disease, which may be symptomatic or asymptomatic.

Determining the Underlying Condition

Considering the strong association between the identified skin disorder (Dermatitis Herpetiformis) and gastrointestinal conditions, celiac sprue stands out as the condition that predisposes individuals to this specific type of skin eruption.

  • Celiac sprue
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Important Questions from Skin Infections

  1. Type-2 necrotizing fasciitis is caused by
  2. Tinea versicolor is caused by:
  3. Herald patch followed by rash is characteristic of:
  4. Consider the following statements: 

    1. Boils/suppurative lesions around the nose must be promptly treated with antibiotics. 

    2. Suppurative lesions around the nose lead to cavernous sinus thrombosis. 

    Which of the statements given above is/are correct?

  5. Match List I with List II

    List I (Physical Sign)List II (Medical Condition)
    A. Koebner phenomenon 1. Lepra reaction
    B. Erytdema nodosum2. Pemphigus vulgaris
    C. Erytdema multiforme3. Stevens-Johnson syndrome
    D. Nikolsky's sign4. Psoriasis
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