Question
Which Residue is removed from DNA by base excision repair process ?
The correct answer is
Uracil
Base Excision Repair Targets Uracil Residues
The Base Excision Repair (BER) pathway is a crucial cellular mechanism designed to correct specific types of DNA damage.
- BER primarily targets non-helix distorting DNA lesions.
- These lesions often involve modified or incorrectly incorporated bases.
- A common substrate for BER is Uracil (U).
Uracil Removal in DNA
Uracil can arise in DNA through two main routes:
- Cytosine deamination: Cytosine (C) can spontaneously deaminate to form Uracil (U). If not repaired, this can lead to a C-to-T transition mutation during replication.
- Incorporation during replication: Although rare, Uracil can be mistakenly incorporated instead of Thymine (T) by DNA polymerases.
The BER pathway efficiently recognizes and removes Uracil from the DNA strand. This process typically involves a DNA glycosylase enzyme that cleaves the glycosidic bond between the Uracil base and the deoxyribose sugar, initiating the repair cascade.
Therefore, Uracil is the specific residue commonly removed by the base excision repair process.
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Important Questions from Miscellaneous
- Which of the following relationships is/are not true?
(A). Most probable velocity = $\sqrt{\frac{2RT}{M}}$
(B). PV = $\frac{3}{2}kT$
(C). Compressibility factor Z = $\frac{pV}{nRT}$
(D). Average kinetic energy of gas = $\frac{1}{2}kT$
Choose the correct answer from the options given below - Match List-I with List-II
List-I List-II Electronic Configuration First Ionisation energy (kJ mol$^{-1}$) (A). ns$^2$ (I). 2100 (B). ns$^2$np$^1$ (II). 1400 (C). ns$^2$np$^3$ (III). 800 (D). ns$^2$np$^6$ (IV). 900
Choose the correct answer from the options given below: - The shielding constant of a 2p electron (calculated using Slater's rules) is
- Match List-I with List-II
List-I List-II Spectroscopy Property (A). Raman (I). Polarizability (B). FTIR (II). Dipole Moment (C). UV-Visible (III). Absorbance (D). NMR (IV). Spin
Choose the correct answer from the options given below: - The structure of protein comprises of:
(A). Primary structure of protein is associated with amino acids
(B). Secondary structure of protein is associated to peptides
(C). Tertiary structure of protein is associated with polypeptide chains
(D). Quaternary structure of protein is associated with polypeptide chains
Choose the correct answer from the options given below:
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