Peptic Ulcer Prophylaxis: Evaluating Statements
This question requires identifying the correct statement regarding the prevention (prophylaxis) of peptic ulcers, particularly in a clinical context.
Analyzing Prophylaxis Statements
- Statement 1: Stress ulceration during clinical illness is uncommon. This is incorrect. Stress ulceration is relatively common in critically ill patients due to physiological stress.
- Statement 2: Ulcer prophylaxis should be continued once absorption of enteral feed is established. This statement is not universally correct. While enteral feeding can help, the decision to continue prophylaxis depends on the patient's overall risk factors and clinical stability. It's not an automatic continuation.
- Statement 3: Proton-pump inhibitors (PPIs) are effective at reducing the incidence of ulceration. This statement is correct. PPIs are widely used and proven effective in preventing stress-related mucosal damage and peptic ulceration in high-risk patients.
- Statement 4: PPIs when used with antibiotics may decrease the risk of Clostridium difficile infection. This statement is incorrect. PPI use, especially alongside antibiotics, is generally associated with an increased risk of Clostridium difficile infection, not a decreased risk.
Conclusion on PPI Effectiveness
Based on clinical evidence, Proton-pump inhibitors (PPIs) play a significant role in the prophylaxis of peptic ulcers by reducing gastric acid production, thereby protecting the gastric mucosa from damage.
Important Questions from Peptic Ulcer Disease
With regard to Helicobacter pylori eradication in peptic ulcer disease, consider the following statements:
1. Proton-pump inhibitor is taken with two antibiotics.
2. Treatment is prescribed for at least 7 days.
3. Treatment of Helicobacter pylori infection leads to vitamin B12 deficiency.
4. Patients requiring long-term NSAIDS should undergo Helicobacter pylori eradication therapy to reduce ulcer risk.
Which of the statements given above are correct?
- The investigation of choice for early follow-up in patients treated for anti-$H.$ pylori drugs is
- The most common non-pancreatic site for tumour distribution in Zollinger-Ellison syndrome is
- Helicobacter pylori infection is associated with the development of which one of the following lymphoid malignancies?
- Which one of the following statements about Barrett's Oesophagus is NOT correct?
