fIPV Dose Comparison with I/M IPV
The question compares the dose of intra-dermal fractional Inactivated Polio Vaccine (fIPV) with the standard intramuscular (I/M) IPV dose.
The standard I/M dose of IPV is 0.5 mL. The fractional intra-dermal dose (fIPV) used in immunization programs is 0.1 mL, administered intra-dermally rather than intramuscularly. This intra-dermal route allows a smaller antigen dose to still generate adequate immunogenicity because the dermis is rich in antigen-presenting (Langerhans) cells.
Calculating the ratio: 0.1 mL / 0.5 mL = 1/5. Hence, fIPV is one-fifth of the standard I/M IPV dose, not three-fourths, half, or one-tenth.
Option-wise Analysis
- fIPV is one-tenth of the I/M dose of IPV — Incorrect. This would mean 0.05 mL, which is not the fractional dose used; the actual fIPV dose is 0.1 mL.
- fIPV is three-fourth of the I/M dose of IPV — Incorrect. This is not how fractional dosing works; three-fourths (0.375 mL) is far higher than the actual fractional dose and is not a recognized fIPV regimen.
- fIPV is half of the I/M dose of IPV — Incorrect. Half the I/M dose would be 0.25 mL, which does not match the standard fIPV dose of 0.1 mL.
- fIPV is one-fifth of the I/M dose of IPV — Correct. The standard fIPV dose (0.1 mL) is exactly one-fifth of the standard I/M IPV dose (0.5 mL), making this the accurate statement.
Therefore, the correct answer is that fIPV is one-fifth of the I/M dose of IPV.
Important Questions from Child Immunization
Which of the following are correct with regard to BCG vaccination?
1. It is a live-attenuated vaccine.
2. It is administered by intramuscular injection.
3. It is derived from Mycobacterium bovis.
4. It is highly immunogenic.
Select the answer using the code given below :
Consider the following statements :
1. Hepatitis B vaccine has reduced efficacy, if administered intramuscularly.
2. The maximum time allowed between reconstitution of MMR vaccine and use is 30 minutes.
3. Maternal antibodies do not interfere with cellular immune response to BCG vaccine.
4. DTwP is preferred to DTaP for primary immunization in most children.
Which of the statements given above are correct?
- Rotavirus vaccination is avoided during an episode of diarrhoea because
- The event related to vaccination which can be contraindication for the next vaccination of similar/identical type is
Which of the following events could be caused or precipitated by an active component of vaccine?
1. Anaphylaxis after measles vaccine
2. Encephalopathy after DPT vaccine
3. Adenitis following BCG vaccine
4. Gastroenteritis following MMR vaccine
Select the correct answer using the code given below.
