To determine the next image in the given series, we need to observe the pattern in the sequence of images:

1. Each box in the series is divided into four smaller squares, each containing one letter. Some boxes have a symbol in one of the squares.
2. Notice that in the images provided in the question, the letters are being rotated in a clockwise direction.
3. We can see that the letters appear to rotate 90 degrees clockwise from one box to the next in the sequence.
4. The symbols also move to the next square in a clockwise direction.

By applying the same logic to the last visible box in the sequence, we predict the arrangement in the next box:

• If the letters in the initial series move 90 degrees clockwise, we check each option to find an image that continues this pattern.

Let's analyze the options:

• Option 1: The arrangement of letters does not match the pattern.
• Option 2: The arrangement of letters does not match the pattern.
• Option 3: The arrangement of letters does not match the pattern.
• Option 4: This option continues the pattern perfectly by rotating the letters and moving the symbol correctly.

Thus, the correct next image in the series is Option 4, as it follows the observed rotation pattern.