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Question

Which of the following insulins has a cloudy preparation and requires resuspension prior to injection?

The correct answer is
Lente

Insulin Preparation and Resuspension

The question asks to identify the specific type of insulin that is characterized by a cloudy appearance and necessitates resuspension before administration via injection.

Lente Insulin Characteristics

Lente insulin is an intermediate-acting insulin preparation. Unlike many other insulin types, Lente is formulated as a suspension. Suspensions are inherently cloudy due to the presence of suspended particles. This physical state requires gentle mixing or rolling of the vial or pen before each use to ensure a uniform dose is delivered.

Comparison with Other Insulin Types

The other insulin options provided represent different classes:

  • Glargine, Detemir, and Degludec are all types of long-acting basal insulins. These are typically formulated as clear solutions. Clear insulin solutions do not require resuspension because the insulin is fully dissolved. Shaking or vigorous mixing is generally discouraged for these clear insulins as it can damage the insulin molecules.

Conclusion on Resuspension

Therefore, the insulin type that has a cloudy preparation and requires resuspension prior to injection is Lente insulin.

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Important Questions from Diabetes Mellitus

  1. All of the following are clinical features of Polycystic ovarian syndrome EXCEPT:
  2. Which one of the following is NOT the criterion for the diagnosis of Diabetes mellitus?
  3. Consider the following statements about erectile dysfunction in diabetic males:
    1. It affects 60% of males
    2. Its common cause is an underlying neuro-vascular pathology
    3. It may be aggravated by beta-adrenergic agonist drugs
    4. Endocrine disorders like hyperprolactinemia may cause it
    Which of the statements given above are true?
  4. Syndrome X includes:
  5. All of the following insulins are longer acting EXCEPT:
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