Insulin Preparation and Resuspension
The question asks to identify the specific type of insulin that is characterized by a cloudy appearance and necessitates resuspension before administration via injection.
Lente Insulin Characteristics
Lente insulin is an intermediate-acting insulin preparation. Unlike many other insulin types, Lente is formulated as a suspension. Suspensions are inherently cloudy due to the presence of suspended particles. This physical state requires gentle mixing or rolling of the vial or pen before each use to ensure a uniform dose is delivered.
Comparison with Other Insulin Types
The other insulin options provided represent different classes:
- Glargine, Detemir, and Degludec are all types of long-acting basal insulins. These are typically formulated as clear solutions. Clear insulin solutions do not require resuspension because the insulin is fully dissolved. Shaking or vigorous mixing is generally discouraged for these clear insulins as it can damage the insulin molecules.
Conclusion on Resuspension
Therefore, the insulin type that has a cloudy preparation and requires resuspension prior to injection is Lente insulin.
Important Questions from Diabetes Mellitus
- A 52-year-old male diabetic presents with recurrent episodes of hypoglycemia. On examination, Pulse : 84 beats/minute, BP : 160/100 mm Hg, Chest and CVS examination unremarkable. Which of the following antihypertensive should be avoided in this patient ?
- Which of the following glucose lowering agent can be given as an injectable drug?
Which of the following findings are seen in Diabetic Retinopathy on fundus examination?
1. Microaneurysm
2. Dot and blot hemorrhage
3. Retinal thickening
4. Neovascularization
Select the correct answer using the code given below:
Which of the following statements are correct with regard to glucose homeostasis?
1. Insulin level rises postprandially.
2. Major portion of postprandial glucose is used by skeletal muscle.
3. Brain uses glucose in an insulin-dependent manner.
4. Glucagon is secreted during exercise.
Select the answer using the code given below :
Consider the following pancreatic hormones :
1. Insulin
2. Islet amyloid polypeptide or amylin
3. Glucagon
4. Somatostatin
Which of the above is/are secreted by beta cells of the pancreatic islets?
