1. It is most effective for relieving tremors
2. Only a small portion of total drug reaches the brain
3. Nausea may be offset by domperidone
4. It may trigger hallucinations
Select the correct answer using the code given below :
Levodopa Statements Analysis
This section analyzes the accuracy of four statements concerning the drug Levodopa.
Levodopa Tremor Effectiveness
Levodopa is primarily effective for improving rigidity and bradykinesia in Parkinson's disease. While it can help with tremors, it is not usually considered the most effective treatment specifically for this symptom compared to other motor symptoms.
Levodopa Brain Delivery
Levodopa undergoes significant peripheral metabolism by DOPA decarboxylase. As a result, only a small fraction of the administered dose successfully crosses the blood-brain barrier to reach the brain.
Levodopa Nausea Management
Nausea is a common side effect of Levodopa. Domperidone, a peripheral dopamine antagonist, can be administered to help manage this specific side effect.
Levodopa Hallucinations
Hallucinations represent a potential central nervous system (CNS) adverse effect associated with Levodopa therapy, often linked to dopaminergic overstimulation.
Summary of Correct Levodopa Statements
Based on the analysis:
- Statement 1 is incorrect regarding Levodopa being most effective for tremors.
- Statement 2 is correct about limited brain delivery.
- Statement 3 is correct regarding domperidone for nausea.
- Statement 4 is correct about hallucinations as a side effect.
Therefore, statements 2, 3, and 4 are correct.
Important Questions from Neuropathies
Consider the following clinical features :
1. Hypomimia
2. Dysphonia
3. Festination gait
4. Cogwheel rigidity
Which of the features given above are generally present in Parkinsonism?
- Circuits between the basal ganglia and the motor cortex constitute the extra pyramidal system which controls muscle tone, body posture and the initiation of movement. Lesions of the extra pyramidal system present clinically with :
Consider the following statements regarding Transient Global Amnesia (TGA):
1. TGA mainly affects middle aged persons who present with abrupt, discrete loss of anterograde memory lasting for few hours.
2. During the episode, the patients are unable to record new memories resulting in repetitive questioning.
3. Consciousness is impaired during the episode and the patient is unable to perform even simple motor functions.
4. After 4-6 hours, memory function and behaviour return to normal but the patient has complete and persistent amnesia for the duration of the episode.
Which of the statements given above are correct?
- Which of the following correctly describes the primary position of the right eye in right 3rd cranial nerve palsy?
- Which one of the following distinguishes axonal degeneration from segmental demyelination on electrophysiological studies?
