Which of the following antidepressant drugs act by inhibition of monoamine oxidase? 1. Phenelzine 2. Tranylcypromine 3. Dosulepin 4. Moclobemide Select the correct answer using the code given below:
Identifying MAO Inhibitor Antidepressants
The question asks to identify antidepressant drugs that function by inhibiting monoamine oxidase (MAO). MAO is an enzyme responsible for breaking down neurotransmitters like serotonin, norepinephrine, and dopamine. Inhibiting MAO increases the levels of these neurotransmitters, which is the therapeutic effect in treating depression.
Mechanism of Action Analysis
Let's analyze the mechanism of action for each drug listed:
- 1. Phenelzine: This is a classic, irreversible monoamine oxidase inhibitor (MAOI). It effectively prevents the breakdown of monoamine neurotransmitters.
- 2. Tranylcypromine: Similar to phenelzine, this drug is also an irreversible MAOI, leading to increased levels of key neurotransmitters in the brain.
- 3. Dosulepin: This is a tricyclic antidepressant (TCA). TCAs primarily work by blocking the reuptake of norepinephrine and serotonin, not by inhibiting MAO.
- 4. Moclobemide: This drug is a selective and reversible inhibitor of monoamine oxidase A (RIMA). Although reversible, it still inhibits MAO activity, fitting the criteria.
Conclusion on MAO Inhibition
Based on the analysis, the drugs that act by inhibition of monoamine oxidase are:
- Phenelzine (MAOI)
- Tranylcypromine (MAOI)
- Moclobemide (RIMA, a type of MAO inhibition)
Dosulepin does not inhibit MAO.
Therefore, the correct combination including drugs that inhibit monoamine oxidase is 1, 2, and 4.
Important Questions from Depression
Which of the following are selective serotonin re-uptake inhibitors?
1. Escitalopram
2. Amitriptyline
3. Fluoxetine
4. Sertraline
Select the correct answer using the code given below:
- A particularly chronic low-grade long lasting depression is known as
