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Question

Which ECG change best differentiates left ventricular hypertrophy from simple increased cardiac workload without structural enlargement?

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The correct answer is

Increased QRS voltage with secondary ST–T changes

Left ventricular hypertrophy is defined on the ECG not merely by higher voltage but by increased QRS voltage accompanied by secondary ST–T changes — a down-sloping ST depression and T-wave inversion in the leads with the tall R waves ('LV strain pattern') — reflecting true structural hypertrophy rather than functional overload alone.

Uniform ST depression without voltage change, isolated PR prolongation and axis deviation with normal QRS amplitude do not distinguish structural hypertrophy from mere increased workload.

Hence, Increased QRS voltage with secondary ST–T changes.

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Important Questions from Basic Cardiovascular Investigations

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