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Question

What is the route of administration of the drug Nitroglycerine?

The correct answer is Sublingual

The correct answer is Sublingual.

Nitroglycerine undergoes extensive hepatic first-pass metabolism, so for acute angina it is given sublingually (0.3–0.6 mg tablet or spray). It is absorbed through the oral mucosa directly into the systemic circulation and acts within 1–3 minutes; the dose may be repeated every 5 minutes up to 3 doses.

Oral sustained-release forms are used only for prophylaxis; IM is not used; IV infusion is reserved for unstable angina or acute heart failure in hospital.

Short trick: Angina attack → NTG under the tongue, max 3 doses 5 minutes apart.

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