Question
Use of which of the following drugs may result in osteoporosis ?
1. Phenytoin
2. Lithium
3. Methotrexate
4. Azathioprine
Select the correct answer using the code given below :
The correct answer is
1, 2 and 3
The question asks to identify drugs from the list that can lead to osteoporosis.
Drugs Causing Osteoporosis
Certain medications are known to affect bone metabolism and can increase the risk of developing osteoporosis, a condition characterized by weakened bones.
Analysis of Drugs
- Phenytoin: This anticonvulsant medication can interfere with Vitamin D metabolism and calcium absorption, contributing to bone density loss and potentially causing osteoporosis.
- Lithium: Commonly used to treat bipolar disorder, lithium can affect parathyroid hormone levels, potentially leading to hyperparathyroidism and subsequent bone loss.
- Methotrexate: Used in treating various autoimmune conditions and cancers, methotrexate has been associated with decreased bone mineral density. Its mechanism might involve inhibiting osteoblast activity.
- Azathioprine: While primarily an immunosuppressant, azathioprine is less directly linked to causing osteoporosis compared to the other drugs listed. However, the conditions treated with azathioprine might involve other factors contributing to bone loss.
Conclusion on Drug Association
Based on established medical literature, Phenytoin (1), Lithium (2), and Methotrexate (3) are recognized as drugs that may result in osteoporosis.
Therefore, the correct combination is 1, 2, and 3.
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Important Questions from Osteoporosis
- Which of the following are correct with regard to osteoporosis ?
1. It does not cause symptoms until a fracture occurs
2. Vertebral fracture can present with loss of height, in absence of pain
3. Smoking is protective
4. It sometimes presents incidentally as radiological osteopenia
Select the correct answer using the code given below : - First line drug treatment to reduce fractures in osteoporosis is :
- Elevated serum alkaline phosphatase is seen in all except:
- Which one of the following is the most common site for a fracture associated with osteoporosis ?
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