Folic Acid Dosage for Neural Tube Defect Prevention
For expectant mothers with a history of a previous fetus affected by a neural tube defect (NTD), a higher daily dose of folic acid is recommended to prevent recurrence. This is considered secondary prevention.
- The recommended daily dose for secondary prevention of NTDs is 4 mg.
- This dose is significantly higher than the standard 400 $\mu$g (0.4 mg) recommended for women without a history of NTDs.
- The high-dose folic acid supplementation should ideally begin before conception and continue through the first trimester of pregnancy.
Therefore, expectant mothers with a previous NTD-affected fetus should receive folic acid daily at the dose of 4 mg.
This corresponds to Option C.
Important Questions from Congenital Disorders
Consider the following statements regarding non-invasive prenatal screening (NIPS) for screening high risk pregnancies for aneuploidies:
1. It is carried out on maternal blood.
2. It is done before 10 weeks gestation.
3. It has a negative predictive value of about 98%.
4. Invasive testing is needed for confirmation of a positive test.
Which of the statements given above are correct?
- The risk of Down syndrome is 100% in the offspring, if:
Which of the following are examples of genomic imprinting?
1. Angelman syndrome
2. Williams syndrome
3. Prader-Willi syndrome
4. DiGeorge syndrome
Select the correct answer using the code given below:
- To reduce the risk of neural tube defects in the baby, which of the following are recommended?
- A tall thin adolescent boy is found to have gynaecomastia and small testes. His blood testosterone level is undetectable, and serum FSH and LH levels are elevated. Which one of the following is the likely karyotype pattern?
