The standard free energy (kJ mol–1) of hydrolysis of glucose-1-phosphate is:
-20.9
Hydrolysis of Glucose-1-Phosphate
Hydrolysis is a chemical reaction where a molecule reacts with water, causing the molecule to break down into smaller components. In biological systems, the hydrolysis of certain molecules, particularly those with high-energy phosphate bonds, releases a significant amount of energy.
Standard Free Energy of Hydrolysis
The standard free energy change ($\Delta G^\circ$) is a thermodynamic quantity that predicts the spontaneity of a reaction under standard conditions. These conditions are typically 25°C (298 K), 1 atmosphere of pressure, and reactants and products initially at 1 M concentration (or 1 bar partial pressure for gases). For biochemical reactions, the standard conditions often include a pH of 7.0 (indicated as $\Delta G^{\circ \prime}$) because this is the physiological pH.
A negative value for $\Delta G^\circ$ (or $\Delta G^{\circ \prime}$) indicates that the reaction is exergonic, meaning it will release energy and can proceed spontaneously under standard conditions. A positive value indicates an endergonic reaction, which requires energy input to occur.
Glucose-1-Phosphate Hydrolysis Value
Glucose-1-phosphate is an activated form of glucose involved in pathways like glycogen synthesis and degradation. Its hydrolysis reaction can be written as:
Glucose-1-phosphate + H$_2$O $\rightarrow$ Glucose + Pi (Inorganic Phosphate)
The standard free energy of hydrolysis ($\Delta G^{\circ \prime}$) for glucose-1-phosphate has been experimentally determined. This value represents the energy released when glucose-1-phosphate is hydrolyzed under standard biochemical conditions (pH 7.0).
The standard free energy of hydrolysis of glucose-1-phosphate is approximately:
\(\Delta G^{\circ \prime} = -20.9 \text{ kJ mol}^{-1}\)
This value shows that the hydrolysis of glucose-1-phosphate is an exergonic reaction, releasing energy that can be utilized by the cell for other processes.
Comparing Hydrolysis Energies
It's helpful to compare this value to the hydrolysis energy of other phosphate compounds. For instance, the hydrolysis of ATP to ADP and Pi has a $\Delta G^{\circ \prime}$ of about -30.5 kJ mol\(^{-1}\), and the hydrolysis of glucose-6-phosphate has a $\Delta G^{\circ \prime}$ of about -13.8 kJ mol\(^{-1}\). The value for glucose-1-phosphate (-20.9 kJ mol\(^{-1}\)) falls between these, indicating it releases a moderate amount of energy upon hydrolysis, making it suitable for its roles in metabolic pathways.
Important Questions from Biochemistry
The following table lists names of scientists and advances made by them
Column A Column B A Linus Pauling (i) Myoglobin structure B Emil Fischer (ii) Model of α-helix C John Kendrew (iii) Lock and Key model D Christian Anfinsen (iv) Sequence-structure
Which one of the following options correctly matches contents of column A with column B?One gram of a polysaccharide composed of 1000 glucose units has the same effect on osmolarity as that of
Several proteins are modified by phosphorylation at specific amino acid residues to alter their activities. Which one of the following amino acids is NOT typically a site of phosphorylation in proteins?
The following statements are made with regard to the optical activity of amino acids derived from natural proteins:
A. All alpha-amino acids have the D stereochemical configuration.
B. All L-amino acids have the (S) absolute configuration except cysteine, which has the (R) absolute configuration.
C. All D-amino acids have the (S) absolute configuration except cysteine, which has the (R) stereochemical configuration.
D. In the absolute configuration system, L-threonine and L-isoleucine are (2S, 3R)-threonine and (2S, 3S)-isoleucine diastereomers, respectively.
Which one of the following options represents the combination of all correct statements?
How long should it take the polypeptide backbone of a 6-residue, 10-residue, 15-residue and 20-residue folding nucleus to explore all its possible conformations? Assume that the polypeptide backbone randomly reorients every 10-13 seconds (s).
