Colon Cancer Predisposing Conditions
Several gastrointestinal conditions significantly increase the risk of developing colon carcinoma. Identifying these predisposing factors is crucial for risk assessment and management.
Conditions Increasing Colon Cancer Risk
The following conditions are well-established risk factors for colon carcinoma:
- Ulcerative colitis: This chronic inflammatory bowel disease causes persistent inflammation of the colon, which over time, elevates the risk of cancerous changes. The longer the duration and extent of colitis, the higher the risk.
- Villous adenoma: These are a specific type of colorectal polyp. Villous adenomas have a higher potential for malignant transformation into adenocarcinoma compared to other types of polyps like tubular adenomas.
- Familial polyposis coli (FAPC): Also known as Familial Adenomatous Polyposis (FAP), this is an inherited genetic disorder characterized by the development of hundreds to thousands of adenomatous polyps in the colon and rectum. Without intervention (like colectomy), FAP almost invariably leads to colon cancer, often by age 40.
Peutz-Jeghers Syndrome and Colon Cancer Risk
Peutz-Jeghers syndrome (PJS) is an inherited disorder associated with hamartomatous polyps throughout the gastrointestinal tract and characteristic mucocutaneous pigmentation (freckles around the mouth, eyes, and nose). While PJS does increase the overall risk of various gastrointestinal and non-gastrointestinal cancers (including small intestine, stomach, pancreas, breast, and ovarian cancers), it is not considered a primary predisposing condition specifically for colon carcinoma in the same way as the other listed conditions. The polyps in PJS are typically hamartomas, not adenomas, and their malignant potential, particularly for colon cancer, is lower compared to FAP or chronic ulcerative colitis.
Therefore, Peutz-Jeghers syndrome is the exception among the choices provided as a direct predisposing condition for carcinoma of the colon.
Important Questions from Intestines
- An eight month old male child is brought to the emergency with recurrent episodes of screaming and drawing up of legs. The child appears to be listless in between the attacks. Local examination of abdomen reveals feeling of emptiness in the right iliac fossa and blood stained mucus is found on the finger on per rectal examination. The most probable clinical diagnosis in this child is
Which of the following statements regarding Ogilvie's syndrome are correct?
1. It presents as acute large bowel mechanical obstruction
2. Marked caecal dilatation is a common feature on X-ray abdo- men
3. Caecal perforation is a well recog- nized complication of this condi- tion
4. Intravenous Neostigmine is used for the treatment of this condition
Select the correct answer using the code given below :
In familial adenomatous polyposis, which of the following all are true ?
1. Presence of $>100$ colorectal polyps
2. Positive family history
3. Autosomal Recessive inheritance
4. Genetic mutation on Chromo- some 5
Select the correct answer using the code given below :
- Among the extra intestinal manifesta- tions of Crohn's disease which one of the following is related to the disease activity?
Which of the following statements with regard to Enteric perforation are correct?
1. Salmonella typhi is the causative organism for Enteric fever
2. Enteric perforation characteristi- cally occurs during third week of illness
3. Typhoid ulcers are placed trans- versely to the long axis of the gut
4. Terminal ileum is the most common site for enteric perfora- tion
Select the correct answer using the code given below :
