1. Atlas of Protein sequence and structure
2. Atlas of DNA sequence and structure
3. Atlas of RNA sequence and structure
4. Atlas of Protein and Nucleic acid sequence and structure
First Biological Sequence Database: Dayhoff & Eck's Contribution
Understanding the Question
This question asks to identify the very first biological sequence database created. It specifically mentions the developers, Dayhoff and Eck, and the year 1965. The key terms are "first ever biological sequence database".
Analyzing the Options
The options provided are:
- 1. Atlas of Protein sequence and structure
- 2. Atlas of DNA sequence and structure
- 3. Atlas of RNA sequence and structure
- 4. Atlas of Protein and Nucleic acid sequence and structure
These options differ mainly in the type of biological molecule whose sequences they cover (Protein, DNA, RNA, or a combination).
Detailed Explanation
The field of bioinformatics relies heavily on curated databases of biological sequences. The pioneers in this area laid the groundwork for future research.
In 1965, Margaret O. Dayhoff, a biochemist, along with Richard V. Eck, initiated a project to collect and organize protein sequences. This groundbreaking effort resulted in the publication of the "Atlas of Protein Sequence and Structure". This was one of the earliest, if not the very first, systematic compilations of biological sequence data available to the scientific community.
While modern databases encompass a vast range of molecules, including DNA and RNA, Dayhoff's initial focus was on proteins. Her work became a foundational resource for researchers studying protein evolution, function, and structure. Subsequent editions of the Atlas expanded its scope, but the 1965 publication established the concept of a sequence database.
Therefore, the "Atlas of Protein sequence and structure" correctly identifies the first biological sequence database developed by Dayhoff and Eck in 1965.
Important Questions from Miscellaneous
- Which of the following relationships is/are not true?
(A). Most probable velocity = $\sqrt{\frac{2RT}{M}}$
(B). PV = $\frac{3}{2}kT$
(C). Compressibility factor Z = $\frac{pV}{nRT}$
(D). Average kinetic energy of gas = $\frac{1}{2}kT$
Choose the correct answer from the options given below - Match List-I with List-II
List-I List-II Electronic Configuration First Ionisation energy (kJ mol$^{-1}$) (A). ns$^2$ (I). 2100 (B). ns$^2$np$^1$ (II). 1400 (C). ns$^2$np$^3$ (III). 800 (D). ns$^2$np$^6$ (IV). 900
Choose the correct answer from the options given below: - The shielding constant of a 2p electron (calculated using Slater's rules) is
- Match List-I with List-II
List-I List-II Spectroscopy Property (A). Raman (I). Polarizability (B). FTIR (II). Dipole Moment (C). UV-Visible (III). Absorbance (D). NMR (IV). Spin
Choose the correct answer from the options given below: - The structure of protein comprises of:
(A). Primary structure of protein is associated with amino acids
(B). Secondary structure of protein is associated to peptides
(C). Tertiary structure of protein is associated with polypeptide chains
(D). Quaternary structure of protein is associated with polypeptide chains
Choose the correct answer from the options given below:
