The given sentence is missing in the paragraph below. Decide where it best fits among the options 1, 2, 3, or 4 indicated in the paragraph.
Sentence: In each of the affected males, the genetic defect was located to the X chromosome in the region of p11-12. Paragraph: The first suggested evidence of a human genetic mutation associated with aggressive behaviour came from a study in 1993. _____(1)____. Genetic and metabolic studies were conducted on a large Dutch family in which several of the males has a syndrome of borderline mental retardation and abnormal behaviour. _____(2)____. The undesirable behaviour included impulsive aggression, arson and exhibitionism. _____(3)____. A point mutation was identified in the eighth exon of the monoamine oxidase A (MAOA) structural gene which changes glutamine to a termination codon. _____(4)____.
Option 3
The sentence refers to "the affected males", so it must come after the males with the syndrome and their behaviour have been described.
Blank (3) follows the list of behaviours and comes just before the precise point mutation in the MAOA gene.
Locating the defect to a region of the X chromosome first and then naming the exact mutation moves from the broad location to the specific gene, which is the natural order.
Blanks (1) and (2) come before the behaviour is described, and blank (4) would put the broad location after the specific mutation.
Hence, Option 3.
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