Match the immune tolerance mechanisms in Group I with their respective outcomes in Group II.
Group I Group II
P. Anergy 1. Elimination of activated T-cells after antigen clearance
Q. Activation-induced cell death 2. Inhibition of auto-reactive T-cells at periphery
R. Receptor editing 3. Unresponsiveness to antigens due to lack of co-stimulatory molecules
S. Regulatory T-cells 4. Elimination of auto-reactive B-cells

Question

Match the immune tolerance mechanisms in Group I with their respective outcomes in Group II.

Group I	Group II
P. Anergy	1. Elimination of activated T-cells after antigen clearance
Q. Activation-induced cell death	2. Inhibition of auto-reactive T-cells at periphery
R. Receptor editing	3. Unresponsiveness to antigens due to lack of co-stimulatory molecules
S. Regulatory T-cells	4. Elimination of auto-reactive B-cells

Prepp Team · Accepted Answer

This question requires matching immunological tolerance mechanisms with their corresponding outcomes. Let's analyze each item:

Matching Tolerance Mechanisms

P. Anergy: This state involves the inactivation of lymphocytes (primarily T-cells) due to a lack of necessary co-stimulatory signals, leading to unresponsiveness to the specific antigen. This aligns with outcome 3.
Q. Activation-induced cell death (AICD): This is a mechanism that eliminates lymphocytes that have been activated excessively or persistently. It helps to clear activated lymphocytes, particularly T-cells, after an immune response subsides or during prolonged antigen exposure, preventing potential damage. This matches outcome 1.
R. Receptor editing: This is a process observed mainly in developing B-cells where self-reactive B-cell receptors can be modified. If the self-reactivity persists after editing, the B-cell undergoes apoptosis, leading to its elimination. Thus, it results in the elimination of auto-reactive B-cells. This corresponds to outcome 4.
S. Regulatory T-cells (Tregs): These specialized T-cells play a crucial role in maintaining immune homeostasis and preventing autoimmunity by actively suppressing the activity of self-reactive T-cells in the periphery. This matches outcome 2.