Match the drugs in Group I with their mechanism of action in Group II. Group I Group II P) Paclitaxel 1) Inhibits protein translation Q) Colchicine 2) Inhibits microtubule depolymerization R) Etoposide 3) Inhibits DNA replication S) Methotrexate 4) Alkylates DNA 5) Inhibits dihydrofolate reductase 6) Inhibits microtubule polymerization
Drug Mechanisms Matching Solution
This solution matches the drugs from Group I with their primary mechanisms of action from Group II.
P) Paclitaxel Mechanism
Paclitaxel stabilizes microtubules, preventing their disassembly (depolymerization). This disruption halts cell division.
Match: P-2 (Inhibits microtubule depolymerization).
Q) Colchicine Mechanism
Colchicine binds to tubulin, inhibiting the polymerization of tubulin subunits into microtubules. This prevents microtubule formation.
Match: Q-6 (Inhibits microtubule polymerization).
R) Etoposide Mechanism
Etoposide inhibits topoisomerase II, an enzyme crucial for managing DNA structure during replication. This inhibition leads to DNA strand breaks, thus interfering with DNA replication.
Match: R-3 (Inhibits DNA replication).
S) Methotrexate Mechanism
Methotrexate inhibits dihydrofolate reductase (DHFR). This enzyme is vital for synthesizing nucleotide precursors needed for DNA synthesis.
Match: S-5 (Inhibits dihydrofolate reductase).
Final Matching Summary
The correct matching derived from the mechanisms is:
- P) Paclitaxel - 2) Inhibits microtubule depolymerization
- Q) Colchicine - 6) Inhibits microtubule polymerization
- R) Etoposide - 3) Inhibits DNA replication
- S) Methotrexate - 5) Inhibits dihydrofolate reductase
This corresponds to the combination P-2, Q-6, R-3, S-5.
Important Questions from Replication Transcription Splicing and Translation
Messenger RNAs (mRNAs) translate to generate polypeptides and the translation terminates at the UGA, UAG or UAA stop codons. The AGA codon acts as additional stop codon in the mitochondria. The longest possible polypeptide(s) that can be hypothetically translated in the cytosol and/or mitochondria, from the given full length mRNA sequence (36 nucleotides) is/are
5'-AACACCAUGACCCAUGUGGCGAGACGGUAGUUAAAA- 3'
- Which of the following statements about initiation of DNA replication in eukaryotes is/are true?
Match the enzyme (Column I) with its corresponding function (Column II).
Column I Column II P. Primase 1. RNA dependent RNA synthesis Q. Reverse transcriptase 2. DNA dependent DNA synthesis R. RNA Replicase 3. RNA dependent DNA synthesis S. DNA Polymerase III 4. DNA dependent RNA synthesis Which of the following statements regarding the below mentioned mRNA sequence is/are TRUE?
5`-UGAUGAGCCUUAACCGGGAACGAAUUUAAG-3`
- Eukaryotic transcription is carried out by
