Question
Match List I with List II and select the correct answer using the code given below the Lists:
List I (Globin chains) List II (Types of haemoglobin) A. $\alpha_2$ $\beta_2$ 1. Hb A$_2$ B. $\alpha_2$ $\gamma_2$ 2. Hb A C. $\alpha_2$ $\delta_2$ 3. Hb F D. $\beta_2$ $\beta_2$ 4. Hb H
The correct answer is
A-2, B-3, C-1, D-4
Globin Chain Composition vs Haemoglobin Types
The question requires matching specific globin chain compositions (List I) with their corresponding haemoglobin types (List II).
Key Haemoglobin Compositions
- A. $\alpha_2 \beta_2$: This is the standard structure for Hb A (Haemoglobin A), the most abundant adult haemoglobin.
- B. $\alpha_2 \gamma_2$: This structure defines Hb F (Fetal Haemoglobin), predominant during fetal development.
- C. $\alpha_2 \delta_2$: This represents Hb A$_2$ (Haemoglobin A$_2$), a minor variant found in adult red blood cells.
- D. $\beta_4$ (in the question, notation $\beta_2 \beta_2$ is used): This tetramer of beta chains forms Hb H (Haemoglobin H), an abnormal haemoglobin typically lacking alpha chains.
Correct Matching Summary
Based on the definitions, the correct pairings are:
| List I (Globin Chains) | List II (Haemoglobin Type) |
|---|---|
| A: $\alpha_2 \beta_2$ | 2: Hb A |
| B: $\alpha_2 \gamma_2$ | 3: Hb F |
| C: $\alpha_2 \delta_2$ | 1: Hb A$_2$ |
| D: $\beta_4$ | 4: Hb H |
Therefore, the correct match is A-2, B-3, C-1, and D-4.
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Important Questions from Anemia
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- All of the following cause microcytic hypochromic anemia EXCEPT:
- Pyruvate kinase deficiency results in deficiency of ATP production and a chronic haemolytic anaemia. The disorder is inherited as an:
- Sickle cell disease may be associated with any of the following EXCEPT:
- Every individual carries four alpha gene alleles. Deletion of three alleles leads to development of:
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