Match List I with List II and select the correct answer using the code given below the lists: List I (Endocrinological disorders) List II (Results of investigations) A Hypothyroidism 1 Increased urinary excretion of catecholamines B Cushing's syndrome 2 Increased urinary 17-ketosteroids C Pheochromocytoma 3 Hypocalcaemia and hyperphosphataemia D Hypoparathyroidism 4 TSH levels are increased and $T_3, T_4$ levels are decreased
A-4, B-2, C-1, D-3
Endocrinological Disorders Matching
This question requires matching specific endocrinological disorders with their characteristic investigation results.
Matching List I with List II
Let's match each disorder from List I to its corresponding investigation result in List II:
- A. Hypothyroidism: This condition involves underactive thyroid glands, leading to decreased levels of thyroid hormones ($T_3, T_4$). Consequently, the pituitary gland often increases the secretion of Thyroid Stimulating Hormone (TSH) to compensate. This matches with item 4 (TSH levels are increased and $T_3, T_4$ levels are decreased).
- B. Cushing's syndrome: Characterized by prolonged exposure to high cortisol levels. While direct cortisol measurements are key, conditions involving excess adrenal androgens, sometimes associated with Cushing's syndrome, can result in increased urinary 17-ketosteroids. This matches with item 2 (Increased urinary 17-ketosteroids).
- C. Pheochromocytoma: This is a tumor of the adrenal medulla that produces excessive amounts of catecholamines (like adrenaline and noradrenaline). A key diagnostic finding is the increased excretion of these substances in the urine. This matches with item 1 (Increased urinary excretion of catecholamines).
- D. Hypoparathyroidism: This disorder involves insufficient production of parathyroid hormone (PTH). PTH regulates calcium and phosphate levels. Low PTH leads to low blood calcium levels (hypocalcaemia) and high blood phosphate levels (hyperphosphataemia). This matches with item 3 (Hypocalcaemia and hyperphosphataemia).
Conclusion
Based on the matching:
- A matches with 4
- B matches with 2
- C matches with 1
- D matches with 3
The correct combination is A-4, B-2, C-1, D-3.
| A | B | C | D |
| 4 | 2 | 1 | 3 |
Important Questions from Thyroid Disorders
- Which one of the following diseases is characterized by destructive lymphoid infiltration of the thyroid gland leading to fibrosis and enlargement of the thyroid gland with an increased risk of developing thyroid lymphoma?
With regards to treatment of thyrotoxicosis of Grave's disease, consider the following statements:
1. Propylthiouracil is suitable in breastfeeding patients.
2. Large goitre is an indication for thyroidectomy.
3. Radioiodine is recommended for management in pregnancy.
4. Agranulocytosis is a complication associated with carbimazole.
Which of the statements given above are correct?
With regard to management of hypothyroidism, consider the following statements:
1. Treatment is with levothyroxine replacement.
2. It is taken as a single daily dose.
3. Average dose is 1.6 $\mu$gm/kg/day.
4. Full dose per weight should be started in those with coronary artery disease.
Which of the statements given above are correct?
- Low serum thyroglobulin levels are seen in
- A 27-year lady underwent thyroidectomy for thyroid carcinoma. Post-operatively she started developing muscle cramps, perioral and peripheral paresthesia, and carpopedal spasm. Which one of the following interventions will be appropriate for this patient?
