Question
Match List I with List II and select the correct answer using the code given below the lists:
List I (Diseases) List II (Laboratory parameters) A Thalassemia major 1 Increased serum iron, decreased TIBC, increased serum ferritin B Iron deficiency anaemia 2 Decreased serum iron, increased TIBC, decreased serum ferritin C Nephrotic syndrome 3 Decreased serum iron, decreased TIBC, increased serum ferritin D Acute iron poisoning 4 Increased serum iron, normal TIBC, normal serum ferritin
The correct answer is
A-1, B-2, C-3, D-4
Disease-Laboratory Parameter Matching
This question requires matching specific diseases with their characteristic laboratory findings.
Analysis of Disease-Parameter Pairs
- Thalassemia major (A): An inherited condition causing ineffective red blood cell production and potential iron overload. Laboratory findings often include increased serum iron and increased serum ferritin. TIBC can be normal or decreased. This matches Parameter 1: Increased serum iron, decreased TIBC, increased serum ferritin.
- Iron deficiency anaemia (B): Caused by a lack of iron, leading to reduced haemoglobin. Characteristic lab results are decreased serum iron, decreased serum ferritin, and increased TIBC. This matches Parameter 2: Decreased serum iron, increased TIBC, decreased serum ferritin.
- Nephrotic syndrome (C): This kidney disorder involves significant protein loss, including iron-transport proteins. This leads to decreased serum iron and decreased TIBC. Serum ferritin levels might be increased due to inflammation. This matches Parameter 3: Decreased serum iron, decreased TIBC, increased serum ferritin.
- Acute iron poisoning (D): Results from ingesting large amounts of iron, causing a rapid rise in blood iron levels. The primary finding is markedly increased serum iron. Parameter 4 (Increased serum iron, normal TIBC, normal serum ferritin) represents this state of high acute iron levels.
Identifying the Correct Combination
The derived matches are:
- A → 1
- B → 2
- C → 3
- D → 4
This specific combination (A-1, B-2, C-3, D-4) is presented in the options.
The table representing the correct matching is:
| A | B | C | D |
| 1 | 2 | 3 | 4 |
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Important Questions from Anemia
- A 39-year-old female presents with severe autoimmune hemolytic anemia. Which of the following should be the initial step in its management?
- Which one of the following is a cause of relative erythrocytosis?
- Which one of the following conditions characteristically may present with a triad of haemolysis, pancytopenia and venous thrombosis?
- Which one of the following is associated with low MCV of red blood cells?
- Which one of the following is the primary underlying mechanism of haemolysis in paroxysmal nocturnal haemoglobinuria (PNH)?
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