Question
Match List-I with List-II and select the correct answer using the code given below the lists:
List-I (Disease)
List-II (Cause)A Macrocytic anaemia 1 Iron deficiency B Microcytic anaemia 2 Hypothyroidism C Hemolytic anaemia 3 Vitamin $B_{12}$ deficiency D Megaloblastic anaemia 4 Alpha methyldopa
The correct answer is
A-2, B-1, C-4, D-3
Disease-Cause Matching: MCQs Explained
This section provides a step-by-step solution for matching diseases in List-I with their corresponding causes in List-II.
Matching Analysis
The correct matching is determined by understanding the etiology of each listed disease:
- A. Macrocytic anaemia: Characterized by abnormally large red blood cells. While Vitamin B12 deficiency causes megaloblastic anaemia (a type of macrocytic anaemia), Hypothyroidism (2) can also be associated with macrocytosis.
- B. Microcytic anaemia: Involves red blood cells that are smaller than normal. This is typically caused by Iron deficiency (1), affecting hemoglobin production.
- C. Hemolytic anaemia: Defined by the destruction of red blood cells occurring faster than production. Alpha methyldopa (4) is a medication known to induce immune hemolytic anaemia.
- D. Megaloblastic anaemia: A specific form of macrocytic anaemia due to impaired DNA synthesis, most commonly caused by Vitamin $B_{12}$ deficiency (3) or folate deficiency.
Final Matches and Correct Option
Based on this analysis, the correct pairings are:
- A matches with 2 (Hypothyroidism)
- B matches with 1 (Iron deficiency)
- C matches with 4 (Alpha methyldopa)
- D matches with 3 (Vitamin $B_{12}$ deficiency)
This A-2, B-1, C-4, D-3 mapping corresponds to Option 3.
| A | B | C | D |
| 2 | 1 | 4 | 3 |
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Important Questions from Anemia
- Macrocytosis is seen in all of the following conditions EXCEPT:
- All of the following cause microcytic hypochromic anemia EXCEPT:
- Pyruvate kinase deficiency results in deficiency of ATP production and a chronic haemolytic anaemia. The disorder is inherited as an:
- Sickle cell disease may be associated with any of the following EXCEPT:
- Every individual carries four alpha gene alleles. Deletion of three alleles leads to development of:
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