Understanding Loffler's Syndrome Cause
Loffler's syndrome is a clinical condition characterized by transient pulmonary infiltrates accompanied by eosinophilia in the blood and lungs.
Identifying the Infecting Agent
This syndrome is specifically associated with the larval migration phase of certain helminthic (parasitic worm) infections through the lungs. Among the given options, infection by Ascaris (a type of roundworm) is a well-known cause of Loffler's syndrome.
Mechanism of Loffler's Syndrome
- When Ascaris eggs are ingested, larvae hatch in the intestine.
- These larvae penetrate the intestinal wall and migrate through the bloodstream to the lungs.
- As they pass through the lung tissue (alveoli), they cause inflammation and an accumulation of eosinophils, leading to the characteristic infiltrates and symptoms.
- While other parasites like *Strongyloides* can cause eosinophilic lung disease, Ascaris is classically linked to Loffler's syndrome.
Therefore, Loffler's syndrome is caused due to infection by Ascaris.
Important Questions from Metazoan Infections
- Which among the following is the first intermediate host for the parasitic fluke Clonorchis sinensis?
Which among the following are hepatobiliary flukes (trematodes)?
1. Clonorchis sinensis
2. Mansonella perstans
3. Fasciola hepatica
4. Opisthorchis felineus
Select the correct answer using the code given below:
- Which among the following parasitic helminths is a nematode and has zoonotic transmission?
Which of the following statements are correct in respect of scabies?
1. Male mite Sarcoptes scabiei are commonly transferred from an infected person to a non-infected person.
2. Norwegian scabies occur in immunodeficient patients.
3. Permethrin cream (5%) is used for treatment.
4. Pruritus intensifies at night and after hot shower.
Select the answer using the code given below :
Consider the following statements with regard to cysticercosis :
1. It may present as personality change.
2. Subcutaneous nodule may excised for histology.
3. Cerebral signs commonly do not occur until the larvae die, 5-20 years later.
4. Praziquantel can be given for 10 days.
Which of the statements given above are correct?
