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Question

Given below are two statements: one is labelled as Assertion A and the other is labelled as Reason R
Assertion A: Narco analysis is based on the intra veins (I.V) administration of Barbiturate to create the light anesthetic effect. Barbiturate combines with GABA to form a complex which leads to disinhibition of thoughts.
Reason R: Impulse transmission is affected during the complex formation, which leads to enhancement of imagination or thinking process.
In the light of the above statements, choose the most appropriate answer from the options given below

The correct answer is
A is correct but R is not correct

Narco Analysis Mechanism: Assertion A Validity

Assertion A states that Narco analysis uses intravenous (I.V.) administration of Barbiturates to induce a light anesthetic state, leading to the disinhibition of thoughts via Barbiturate-GABA complex formation. This is factually correct. Barbiturates enhance the effect of the neurotransmitter GABA (Gamma-Aminobutyric Acid) at the GABAA receptor, resulting in increased inhibitory signaling in the brain. This effect reduces neuronal excitability and leads to sedation, hypnosis, and crucially, a reduction in conscious control and inhibition, allowing suppressed thoughts or memories to surface more easily.

Narco Analysis Rationale: Reason R Validity

Reason R claims that impulse transmission is affected, leading to an *enhancement* of the imagination or thinking process. While Narco analysis does alter impulse transmission due to the drug's effects, the primary outcome is disinhibition, not necessarily an enhancement of cognitive functions like imagination or general thinking. The process aims to lower psychological defenses and reduce critical judgment, making the subject more suggestible and likely to speak freely. It does not primarily enhance creative thinking or imagination; instead, it reduces the filters that normally govern thought and speech.

Conclusion on Assertion and Reason

Based on the analysis:

  • Assertion A accurately describes the pharmacological basis and immediate effect (disinhibition) of Narco analysis.
  • Reason R incorrectly characterizes the outcome as an enhancement of imagination or thinking, misrepresenting the core principle of disinhibition facilitated by GABAergic modulation.

Therefore, Assertion A is correct, but Reason R is not the correct explanation for Assertion A, nor is it factually correct in its implication about enhancing imagination as the core mechanism.

The correct option is C: A is correct but R is not correct.

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Important Questions from Pharmacology

  1. Patient is allergic to B-lactamase and which of following drug is safe to administer?

  2. The drug prescription is 20mcg, Available dose for a drug is 30mcg/15ml

    How much ml is administered

  3. Steroids are preferably administered once in the:

  4. The antiviral drug among the following is:

  5. Which of the following is an example of dissociative anesthesia?

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