During an acute myocardial infarction, which change in coronary circulation most directly impairs myocardial function?
Decreased oxygen supply
Acute coronary occlusion abruptly reduces blood flow — and therefore oxygen supply — to the dependent myocardium. The resulting ischaemia impairs ATP production, contractile protein function and ionic pumps, directly causing the loss of mechanical function characteristic of acute MI.
Increased venous return, increased preload or increased arterial pressure would raise myocardial oxygen demand but are not the direct coronary-circulation change causing acute dysfunction.
Hence, Decreased oxygen supply.
Similar Questions
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Important Questions from Introduction to Cardiovascular Diseases
Which ECG change is most commonly associated with myocardial ischemia?
A patient presents with chest pain and ST elevation in leads II, III, and aVF. According to the universal definition of MI, which coronary artery is most likely involved, and what is the ECG diagnosis?
Which ECG change is most characteristic of an acute myocardial infarction?
Which segment is primarily analyzed to diagnose an ST-elevation myocardial infarction (STEMI)?
What is a typical ECG finding in patients with cerebral infarct?
