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Consider the following statements regarding Self-amplifying mRNA (saRNA) Vaccine:

1. Unlike traditional vaccines, saRNA vaccines instruct the body to produce antigenic proteins instead of injecting them directly.

2. They require higher doses compared to existing mRNA vaccines to generate an immune response.

3. saRNA vaccines enable self-replication of mRNA, which makes them more effective at lower doses.

Which of the above statements is/are correct?

The correct answer is

1 and 3 only

Why in the News?

"Gennova Biopharmaceuticals Develops Self-Amplifying mRNA Vaccine for Nipah Virus with CEPI Support”

Statement 1: correct

Unlike traditional vaccines that directly introduce antigens into the body, saRNA vaccines deliver instructions to the cells to produce the desired antigenic proteins. This stimulates the immune system without needing to inject the antigen itself.

Statement 2: incorrect

SaRNA vaccines are designed to replicate the mRNA within the body, requiring lower doses compared to traditional mRNA vaccines. The idea that they need higher doses is incorrect since self-replication enhances immune response at smaller amounts.

Statement 3: correct

SaRNA vaccines leverage self-replication of mRNA, allowing them to produce more antigenic proteins with fewer doses. This self-amplification boosts immune response, making these vaccines potentially more efficient and effective with smaller quantities of mRNA compared to traditional vaccines.

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