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Question

Consider the following statements -

1. This type of Immunoglobulin is a type of antibody representing approximately 75% of serum antibodies in humans.

2. It is present in most abundant quantity in the blood circulation

Which type of immunoglobulin is being talked about?

The correct answer is

IgG

Identifying the Type of Immunoglobulin

The question asks us to identify a specific type of immunoglobulin based on two key statements:

  1. This type of Immunoglobulin is a type of antibody representing approximately 75% of serum antibodies in humans.
  2. It is present in most abundant quantity in the blood circulation.

Let's analyze these statements in the context of different types of immunoglobulins (antibodies) found in the human body.

Immunoglobulin Classes and Abundance

There are five major classes of immunoglobulins: IgG, IgA, IgM, IgD, and IgE. Each class has a different structure, location, and function. Their abundance in the serum (the liquid part of the blood) varies significantly.

Let's look at the approximate serum concentrations of the main classes:

Immunoglobulin Class Approximate % of Total Serum Antibodies
IgG $75\% - 80\%$
IgA $10\% - 15\%$
IgM $5\% - 10\%$
IgD $<1\%$
IgE $<1\%$

Matching Statements to Immunoglobulin Characteristics

Statement 1: "This type of Immunoglobulin... representing approximately 75% of serum antibodies in humans."

  • Looking at the table above, IgG is the only immunoglobulin class that makes up approximately $75\%$ to $80\%$ of the total serum antibodies.
  • IgA is the next most abundant, but it is significantly less than $75\%$.
  • IgM, IgD, and IgE are present in much lower percentages in the serum.

Statement 2: "It is present in most abundant quantity in the blood circulation."

  • The serum is the main component carrying antibodies in the blood circulation. Since IgG is the most abundant immunoglobulin in serum, it is also the most abundant antibody in the blood circulation overall.

Both statements strongly point towards the same type of immunoglobulin.

Conclusion

Based on the fact that it constitutes about $75\%$ of serum antibodies and is the most abundant in blood circulation, the immunoglobulin being described is IgG.

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Important Questions from Immune System

  1. Allergy and anaphylaxis are due to -

  2. Cells that release histamine and other vasoactive substances in response to allergens are -

  3. Which is not a part of lymphatic system?

  4. Bacterial infections are generally divided into two broad classes: intracellular and extracellular bacterial infections. Given below are some of the properties which are applicable for bacterial infections.

    A. Humoral immune response is the main protective response against extracellular bacteria.

    B. Innate immunity is not effective against intracellular bacterial pathogens.

    C. Bacterial endotoxins do not induce an innate immune response.

    D. Intracellular bacterial infections generally induce a cell-mediated immune response resulting in secretion of cytokines which activate macrophages.

    Which one of the following combination of statements is correct?

  5. What is the nature of India's indigenous COVID‐19 vaccine?

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