Stored Blood Coagulation Factor Deficiency
Blood stored for transfusion purposes undergoes changes over time. Certain components, including specific coagulation factors, degrade or become less active during storage.
Labile Coagulation Factors
Coagulation factors V and VIII are known as labile factors. They are sensitive to temperature and time and degrade relatively quickly even under proper storage conditions.
- Factor V and Factor VIII have short half-lives and are significantly reduced in concentration in stored red blood cell units.
Stable Coagulation Factors
Other coagulation factors, such as Factor II (Prothrombin), Factor VII, Factor IX, and Factor X, are more stable and remain at higher concentrations in stored blood products for longer periods compared to Factors V and VIII.
Conclusion
Therefore, blood stored in a blood bank is characteristically deficient in the labile coagulation Factors V and VIII.
Important Questions from Pre-operative & Post-operative Care
- Which type of surgery is laparoscopic cholecystectomy classified as?
- A 50-year old lady underwent uneventful bariatric surgery for morbid obesity. On the third post operative day, she develops breathless and pulmonary embolism is suspected. The next investigation to confirm the diagnosis will be:
- Which one of the following is NOT a risk factor for development of venous thrombosis in surgical patients?
- Which one of the following is NOT a complication of massive blood transfusion?
- A 20 year old patient underwent open hernia surgery four days back. He is running fever for the last one day and on local examination the operated site was wet with pus and surrounding redness and edema. The appropriate management would be:
