Stored Blood Coagulation Factor Deficiency
Blood stored for transfusion purposes undergoes changes over time. Certain components, including specific coagulation factors, degrade or become less active during storage.
Labile Coagulation Factors
Coagulation factors V and VIII are known as labile factors. They are sensitive to temperature and time and degrade relatively quickly even under proper storage conditions.
- Factor V and Factor VIII have short half-lives and are significantly reduced in concentration in stored red blood cell units.
Stable Coagulation Factors
Other coagulation factors, such as Factor II (Prothrombin), Factor VII, Factor IX, and Factor X, are more stable and remain at higher concentrations in stored blood products for longer periods compared to Factors V and VIII.
Conclusion
Therefore, blood stored in a blood bank is characteristically deficient in the labile coagulation Factors V and VIII.
Important Questions from Pre-operative & Post-operative Care
- A surgeon is about to start a laparoscopic procedure on a patient. The floor nurse asks the surgeon about the identity of the patient, site of the procedure to be performed and any anticipated critical events during the surgery. These questions are a part of the
- Perioperative benefit from transfusion is with a haemoglobin level of
- A 60 year old lady underwent total abdominal hysterectomy. On the 3rd post operative day she suddenly became breathless while returning from washroom. Her blood pressure recorded was $80/50$ mm of Hg. The most probable diagnosis is
- Perioperative benefit from transfusion is with a haemoglobin level of
- A 20 year old patient underwent open hernia surgery four days back. He is running fever for the last one day and on local examination the operated site was wet with pus and surrounding redness and edema. The appropriate management would be:
