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Question

Biased gene conversion (BGC) has been proposed to cause changes in allele frequencies in a population. Select the statement that is NOT correct about BGC.

The correct answer is

BGC selects against maladaptations resulting in fixation of only advantages mutations.

The question asks to identify the statement that is NOT correct about Biased Gene Conversion (BGC).

Understanding Biased Gene Conversion (BGC)

Biased Gene Conversion (BGC) is a process that occurs during genetic recombination, specifically during meiosis in eukaryotes or homologous recombination in bacteria. It is a non-reciprocal transfer of genetic information where one allele is preferentially converted into another. The bias in BGC is typically driven by molecular features of the DNA sequence, such as GC content (GC-biased gene conversion), rather than the fitness effects of the alleles involved.

Because BGC alters allele frequencies independent of natural selection based on fitness, it is considered a nonadaptive evolutionary force. It can potentially increase the frequency of alleles that are linked to the favored molecular characteristic, even if those alleles are neutral or deleterious in terms of organismal fitness.

Analyzing the Statements

Let's examine each statement based on our understanding of BGC:

  • Statement 1:

    BGC is present in bacteria and eukaryotes suggesting it may be present in the Last Universal Common Ancestor (LUCA).


    This statement suggests a wide phylogenetic distribution of BGC, which is consistent with current understanding. The presence of a process in both bacteria and eukaryotes often leads to hypotheses about its ancient origins, potentially predating the divergence of these domains. This statement is likely correct or a plausible hypothesis.
  • Statement 2:

    BGC can favor the fixation of deleterious donor alleles.


    BGC acts based on molecular bias (e.g., converting AT to GC), not based on whether an allele is beneficial or harmful. If a deleterious allele is linked to the molecular feature favored by BGC (like being a GC allele in a GC-biased system), BGC can increase its frequency and potentially lead to its fixation in the population, despite being deleterious. This statement is correct.
  • Statement 3:

    BGC is an example of nonadaptive evolutionary process.


    As discussed, BGC influences allele frequencies independently of natural selection on fitness. Its direction is determined by molecular factors. Therefore, it is classified as a nonadaptive evolutionary process. This statement is correct.
  • Statement 4:

    BGC selects against maladaptations resulting in fixation of only advantages mutations.


    This statement claims that BGC acts like natural selection, favoring beneficial mutations and opposing harmful ones. This is incorrect. BGC's bias is molecular, not fitness-based. It does not "select against maladaptations" or ensure the fixation of "only advantageous mutations". In fact, it can potentially increase the frequency of deleterious mutations if they are associated with the favored molecular type. Therefore, this statement is NOT correct.

Identifying the Incorrect Statement

Based on the analysis, Statement 4 is the one that does not accurately describe Biased Gene Conversion. BGC does not perform selection based on fitness; its bias is molecular. It can lead to the fixation of neutral or even deleterious mutations, not just advantageous ones.

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Important Questions from Evolutionary Mechanisms

  1. Given below are proposed analogous structures among organisms.

    A. wings of birds and bats

    B. wings of bats and tetrapod digits

    C. tendrils of Vitis and tendrils of pumpkin

    D. tubers of potatoes and sweet potatoes

    E. fins of fish and flippers of a whale

    Which one of the following options correctly states the analogous structures?

  2. Long - term patterns of evolution are shaped by large scale process(s) such as :
    (I) Speciation
    (II) Mass extinction
    (III) Adaptive radiation
    Choose the correct answer:
  3. Speciation means :
  4. Match List I with List II
     

    List I (Term)List II (Definition)
    A. Sympatric
    speciation                
    I. The process by which organisms adapt to changed environmental conditions to form new species in
    a relatively short period.
    B. Parapatric
    speciation
    II. The process of differentiation and acquiring reproductive isolation within the same geographical
    area.
    C. Adaptive
    radiation
    III. Population evolving in different geographical regions due to isolation.
    D. Allopatric
    speciation
    IV. The process of speciation which occurs between adjacent populations within a broadly continuous
    habitat.


    Choose the correct answer from the options given below:

  5. Given below are two statements: one is labelled as Assertion A and the other is labelled as Reason R 

    Assertion A: Theoretically, natural selection moulds and shapes populations through differential fertility and mortality. 

    Reason R: Sickle cell provides a persuasive argument for differential mortality, affecting populations in malarial environment, but evidence for differential fertility is far from unequivocal. 

    In the light of the above statements, choose the most appropriate answer from the options given below

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