A patient with a peptic ulcer is prescribed a proton pump inhibitor and advised to avoid NSAIDs. Which rationale best explains this combined approach?
To promote ulcer healing and prevent further irritation
A proton pump inhibitor (e.g. omeprazole) blocks the H+/K+ ATPase of parietal cells, reducing gastric acid secretion so the ulcer can heal.
NSAIDs inhibit prostaglandins that protect the gastric mucosa (mucus, bicarbonate, blood flow), so avoiding them prevents further mucosal irritation and new ulcers.
Together the two measures promote healing and prevent re-injury. The approach does not aim to increase acid, improve nutrient absorption or prevent dehydration.
Hence, To promote ulcer healing and prevent further irritation.
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