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Question

A 24 year old male presents with consumption of an unknown substance. His respiratory rate is 22/minute, pulse rate is 110/minute, BP is 150/94 mmHg and he has 2 episodes of seizures. There are tremors and hallucinations. The substance ingested most likely is:

The correct answer is
Amphetamines

Substance Identification Solution

Patient Presentation Analysis

The patient, a 24-year-old male, presents with a constellation of symptoms following the ingestion of an unknown substance. Key clinical findings include:
  • Increased respiratory rate: 22/minute (Tachypnea)
  • Increased pulse rate: 110/minute (Tachycardia)
  • Elevated blood pressure: 150/94 mmHg (Hypertension)
  • Neurological symptoms: 2 episodes of seizures, tremors, and hallucinations

Evaluating Substance Effects

The combination of sympathetic overstimulation (tachycardia, hypertension, tachypnea) and central nervous system excitation (seizures, tremors, hallucinations) points towards a specific class of substances. Let's analyze the options:
  • Amphetamines: These are central nervous system stimulants. Their effects commonly include increased heart rate, blood pressure, and respiratory rate. Neurological effects like tremors, agitation, seizures, and psychosis (including hallucinations) are also characteristic of amphetamine intoxication. This matches the patient's presentation closely.
  • Diazepam: This is a benzodiazepine, a central nervous system depressant. Overdose typically leads to sedation, drowsiness, respiratory depression, and hypotension, which contradicts the patient's vital signs and neurological symptoms.
  • Oxycodone: This is an opioid analgesic, also a central nervous system depressant. Typical overdose symptoms include respiratory depression, extreme drowsiness, pinpoint pupils, and hypotension. This does not align with the patient's presentation.
  • Ethanol: While ethanol intoxication can cause behavioral changes, the specific combination of severe hypertension, marked tachycardia, tachypnea, and seizures is less typical for acute ethanol ingestion compared to stimulants. Ethanol withdrawal can cause tremors and seizures, but this presentation suggests acute intoxication.

Conclusion

Based on the clinical picture of sympathomimetic and CNS stimulant effects, amphetamines are the most likely substance ingested among the choices provided.
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Important Questions from Acute Poisoning

  1. Which of the following toxidromes is associated with the consumption of pesticides containing organophosphates?

  2. Which of the following is the primary antidote used in children with organophosphate poisoning?

  3. Which one of the following drugs is the antidote for benzodiazepine poisoning?
  4. A 3-year old child develops severe respiratory distress after inhalation of fumes arising from burning plastic. The child is started on supportive ventilation. Which one of the following antidotes needs to be given?

  5. All of the following features are present in Organophosphorus poisoning EXCEPT:
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